99mTc ‐labeled oligomeric nanoparticles as potential agents for folate receptor‐positive tumor targeting

One type of biocompatible nanoparticles functionalized with folate and 99mTc was successfully synthesized. Maleimide‐folic acid (Mal‐FA) was selected to covalently conjugate with ‐SH of the nanoparticles (NPs) to prepare NPs‐FA for targeting. 99mTc was selected to conjugate with ‐NH2 and ‐SH groups of cysteine residues on the surface of NPs to prepare NPs‐FA‐99mTc for radioactive counting. The ability to target folate receptors of NPs‐FA‐99mTc was assessed in uptake studies with folate‐receptor–positive human HepG2 cells. The results showed that the as‐prepared NPs can selectively uptake by folate receptor‐overexpressing HepG2 tumor cells in vitro. The oligomeric hybrid NPs radiolabeled with 99mTc may develop to be SPECT/CT imaging biomaterials with high selectivity. One type of biocompatible, oligomeric nanoparticles NPs‐FA‐99mTc was successfully synthesized. The nanoparticle was functionalized with folate (FA) for targeting and 99mTc for radioactive count and imaging. The as‐prepared nanoparticles showed high targeting ability over folate‐receptor‐positive HepG2 tumor cells. The oligomeric hybrid nanoparticles might develop to be SPECT/CT imaging biomaterials with high selectivity.
Source: Journal of Labelled Compounds and Radiopharmaceuticals - Category: Biochemistry Authors: Tags: RESEARCH ARTICLE Source Type: research