Capicua controls Toll/IL-1 signaling targets independently of RTK regulation [Developmental Biology]

The HMG-box protein Capicua (Cic) is a conserved transcriptional repressor that functions downstream of receptor tyrosine kinase (RTK) signaling pathways in a relatively simple switch: In the absence of signaling, Cic represses RTK-responsive genes by binding to nearly invariant sites in DNA, whereas activation of RTK signaling down-regulates Cic activity,...

Source: Proceedings of the National Academy of Sciences - February 20, 2018 Category: Science Authors: Aikaterini Papagianni, Marta Fores, Wanqing Shao, Shuonan He, Nina Koenecke, Maria Jose Andreu, Nuria Samper, Ze’ev Paroush, Sergio Gonzalez–Crespo, Julia Zeitlinger, Gerardo Jimenez Tags: Biological Sciences Source Type: research