Germline mutations of aryl hydrocarbon receptor-interacting protein ( AIP ) gene and somatostatin receptor 1 –5 and AIP immunostaining in patients with sporadic acromegaly with poor versus good response to somatostatin analogues

ConclusionsLack of response to SRLs does not necessarily increase the risk of harboringAIP mutations. The finding of decreasedAIP, SSTR2A, and SSTR2B immunostaining in patients with poor response to SRLs and decreased SSTR2A and SSTR3 level in those with lowAIP immunostaining suggests a possible interaction betweenAIP and some SSTR subtypes that might alter SRL sensitivity.
Source: Pituitary - Category: Endocrinology Source Type: research