Lena Dunham Reveals She Had a Hysterectomy to Stop Pain From Endometriosis

Lena Dunham said she underwent a total hysterectomy — the surgical removal of the cervix and uterus — in an attempt to ease the pain caused by endometriosis. In an essay for the March issue of Vogue, which was excerpted by the Endometriosis Foundation of America, the Girls creator said she had the surgery to address chronic pain from endometriosis, which occurs when the tissue that lines the inside of a woman’s uterus grows in places outside the uterus. Dunham, 31, has been open in the past about her struggle with the condition, which affects about 176 million women across the globe. Dunham wrote in her essay that she elected to have a hysterectomy after “years of complex surgeries measuring in the double digits” and alternative treatments, including yoga, acupuncture and massage therapy. CNN reports that Dunham had to convince doctors that she wanted to have the surgery, which will make her unable to bear children. But Dunham, who said she always wanted to have children, wrote that she’ll now consider surrogacy or adoption. “I may have felt choiceless before, but I know I have choices now,” Dunham wrote. “Soon I’ll start exploring whether my ovaries, which remain someplace inside me in that vast cavern of organs and scar tissue, have eggs. Adoption is a thrilling truth I’ll pursue with all my might.”
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime onetime Women's Health Source Type: news

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Dienogest has been shown to substantially improve endometriosis-associated symptoms such as debilitating chronic pelvic pain, and in turn, health-related quality of life (HRQoL). To date, there is no data on p...
Source: BMC Women's Health - Category: OBGYN Authors: Tags: Research article Source Type: research
This study supports the hypothesis that BDNF and S100B neuromodulators present different serum levels according to the background disease associated to the chronic pain. These have the potential to be studied as markers of active disease or treatment evolution.
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
AbstractEndometriosis is a gynaecological disorder characterised by the presence of endometrial-like tissue outside the uterus. It affects 10 –15% of women during their reproductive age. The existence of close and complex relationship between chronic pelvic pain and endometriosis are widely recognised. However, the mechanisms of pain generation in women with endometriosis remain poorly understood. Immunohistochemistry was used to assess the density of nerve fibres stained with protein gene product 9.5 (PGP9.5) and the expression of various neurotrophins including glial cell derived neurotrophic factor (GDNF), perseph...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
Authors: Barra F, Scala C, Ferrero S Abstract First-line medical therapies for treating pain associated with endometriosis mainly consist in combined oral contraceptives and progestins. However, some women, having persistence of symptoms, may require further therapeutic options. Among these, gonadotropin-releasing hormone (GnRH) agonists (GnRH-as) have been widely employed in the last 30 years, despite being characterized by an unfavorable safety profile. Currently, new alternative investigational options are being investigated to treat this benign chronic disease. GnRH antagonists (GnRH-ants) are innovative hormon...
Source: Drugs of Today - Category: Drugs & Pharmacology Tags: Drugs Today (Barc) Source Type: research
ConclusionProgestin therapy with D or N appears to be effective in reducing the size of endometriomas and related symptoms, with a greater effect on symptoms relief and higher tolerability in women treated with D.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
(Abstracted from J Minim Invasive Gynecol 2019;26:71–77) The primary sequelae of endometriosis are infertility and chronic pelvic pain (CPP). Nearly 40% of women with endometriosis are infertile, and 71% to 87% have CPP.
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: GYNECOLOGY: OPERATIVE GYNECOLOGY Source Type: research
Condition:   Endometriosis Interventions:   Drug: Cabergoline 0.5 MG;   Drug: Placebo - Cap Sponsors:   Boston Children’s Hospital;   Brigham and Women's Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Bulun SE, Yilmaz BD, Sison C, Miyazaki K, Bernardi L, Liu S, Kohlmeier A, Yin P, Milad M, Wei J Abstract Pelvic endometriosis is a complex syndrome characterized by an estrogen-dependent chronic inflammatory process that affects primarily pelvic tissues, including the ovaries. It is caused when shed endometrial tissue travels retrograde into the lower abdominal cavity. Endometriosis is the most common cause of chronic pelvic pain in women and is associated with infertility. The underlying pathologic mechanisms in the intracavitary endometrium and extra-uterine endometriotic tissue involve defectively progr...
Source: Endocrine Reviews - Category: Endocrinology Tags: Endocr Rev Source Type: research
ConclusionMinimal preoperative factors are associated with nonresponse for women having surgery for endometriosis. The severity of pain experienced by women with endometriosis may be used to predict their response to surgery.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Conclusion Four types of USL endometriosis were summarized according to the ultrasound characteristics and the distribution of USL involvement was also concluded according to the results of surgery. TVS has significant value in diagnosis of USL endometriosis and can be used as a first-line tool for diagnosis. Ethics Statement The Medical Science Ethics Committee of Shenzhen People’s Hospital approved this study (No. 2018100). Each patient or an appropriate family member provided informed written consent to obtain clinical materials. Author Contributions YZ and BD conceived and designed the whole experiments and ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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