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Lena Dunham Reveals She Had a Hysterectomy to Stop Pain From Endometriosis

Lena Dunham said she underwent a total hysterectomy — the surgical removal of the cervix and uterus — in an attempt to ease the pain caused by endometriosis. In an essay for the March issue of Vogue, which was excerpted by the Endometriosis Foundation of America, the Girls creator said she had the surgery to address chronic pain from endometriosis, which occurs when the tissue that lines the inside of a woman’s uterus grows in places outside the uterus. Dunham, 31, has been open in the past about her struggle with the condition, which affects about 176 million women across the globe. Dunham wrote in her essay that she elected to have a hysterectomy after “years of complex surgeries measuring in the double digits” and alternative treatments, including yoga, acupuncture and massage therapy. CNN reports that Dunham had to convince doctors that she wanted to have the surgery, which will make her unable to bear children. But Dunham, who said she always wanted to have children, wrote that she’ll now consider surrogacy or adoption. “I may have felt choiceless before, but I know I have choices now,” Dunham wrote. “Soon I’ll start exploring whether my ovaries, which remain someplace inside me in that vast cavern of organs and scar tissue, have eggs. Adoption is a thrilling truth I’ll pursue with all my might.”
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime onetime Women's Health Source Type: news

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Authors: Zu M, Meng W, Guo QZ, Liu ZQ Abstract This work aimed to analyze the effect of deep infiltrating endometriosis (DIE) in young women. Twenty-seven cases of patients (below 38-years-old) diagnosed with DIE and admitted to the present hospital from January 2008 to July 2014 were reviewed, and their pre- and postoperative states of illness were summarized. The main preoperative symptoms included dysmenorrhea, chronic pelvic pain, dyspareunia, nodule in rectouterine fossa, and reduced level of fertility. All patients underwent surgery (17 laparoscopies and ten laparotomies). Postoperative pathological explanati...
Source: Clinical and Experimental Obstetrics and Gynecology - Category: OBGYN Tags: Clin Exp Obstet Gynecol Source Type: research
Authors: Liu SJ, Lv W Abstract Deep infiltrating endometriosis (DIE) is a complex disorder that affects 6% to 12% of all women in the reproductive age. In these cases, treatment is more difficult with possible incomplete pain relief and a considerable possibility of recurrence. Here, the authors report a case of a 41-year-old woman with a history of severe dysmenorrhea, dyspareunia, and chronic pelvic pain because of deep infiltrating pelvic and peritoneal endometriosis, who underwent segmental colorectal resection three years ago for large bowel obstruction due to colonic endometriosis. To ensure complete removal ...
Source: Clinical and Experimental Obstetrics and Gynecology - Category: OBGYN Tags: Clin Exp Obstet Gynecol Source Type: research
CONCLUSION: The association of elevated CA-125 levels with a complaint of dysmenorrhea is adequate in a presumptive and accurate diagnosis of endometriosis in this specific group of women with CPP, permitting an early institution of clinical treatment without the need of previous laparoscopic confirmation. PMID: 29734538 [PubMed]
Source: Clinical and Experimental Obstetrics and Gynecology - Category: OBGYN Tags: Clin Exp Obstet Gynecol Source Type: research
Authors: Barra F, Scala C, Mais V, Guerriero S, Ferrero S Abstract INTRODUCTION: Endometriosis is a hormone-dependent benign chronic disease that requires a chronic medical therapy. Although currently available drugs are efficacious in treating endometriosis-related pain, some women experience partial or no improvement. Moreover, the recurrence of symptoms is expected after discontinuation of the therapies. Currently, new drugs are under intense clinical investigation for the treatment of endometriosis. Areas covered: This review aims to offer the reader a complete and updated overview on new investigational drugs ...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
American Journal of Reproductive Immunology, EarlyView.
Source: American Journal of Reproductive Immunology - Category: Allergy & Immunology Authors: Source Type: research
Conclusion: NR4A1 can regulate fibrosis in endometriosis and may serve as a new target for the treatment of endometriosis.Cell Physiol Biochem 2018;46:1078 –1090
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
Publication date: Available online 6 April 2018 Source:Best Practice & Research Clinical Endocrinology & Metabolism Author(s): Ioannis Simitsidellis, Douglas A. Gibson, Philippa T.K. Saunders Endometriosis is a chronic incurable disorder that affects 1 in 10 women of reproductive age: associated symptoms include chronic pain and infertility. The aetiology of endometriosis remains poorly understood but patients, clinicians and researchers are all in agreement that new non-surgical therapies are urgently needed to reduce the severity of symptoms. Preclinical testing of drugs requires the development and validation o...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
CONCLUSION: A 33-year-old woman developed pancytopenia during a course of fidaxomicin therapy for CDI. Platelet, hemoglobin, and WBC values returned to normal within 3 days of the final fidaxomicin dose. PMID: 29626003 [PubMed - in process]
Source: American Journal of Health-System Pharmacy : AJHP - Category: Drugs & Pharmacology Authors: Tags: Am J Health Syst Pharm Source Type: research
Endometriosis is a chronic incurable disorder that affects 1 in 10 women of reproductive age: associated symptoms include chronic pain and infertility. The aetiology of endometriosis remains poorly understood but patients, clinicians and researchers are all in agreement that new non-surgical therapies are urgently needed to reduce the severity of symptoms. Preclinical testing of drugs requires the development and validation of models that recapitulate the key features of the disorder. In this review we describe the best-validated animal models (primate, rodent, xenograft) and their contributions to our understanding of the...
Source: Best Practice and Research. Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Source Type: research
Endometriosis is a chronic incurable disorder that affects 1 in 10 women of reproductive age: associated symptoms include chronic pain and infertility. The aetiology of endometriosis remains poorly understood but patients, clinicians and researchers are all in agreement that new non-surgical therapies are urgently needed to reduce the severity of symptoms. Preclinical testing of drugs requires the development and validation of models that recapitulate the key features of the disorder. In this review we describe the best-validated animal models (primate, rodent, xenograft) and their contributions to our understanding of the...
Source: Best Practice and Research. Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: 2 Source Type: research
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