DNA demethylation of claudin-4 suppresses migration and invasion in laryngeal squamous carcinoma cells

Claudin-4 (CLDN4) is a member of the claudin transmembrane protein family, which consists of integral membrane proteins that are components of the epithelial cell tight junctions; these tight junctions regulate movement of solutes and ions through the paracellular space. CLDN4 is also a differentiation marker and is believed to indicate an epithelial phenotype. However, the role of CLDN4 in laryngeal squamous carcinoma is still unclear. Here, we showed that CLDN4 expression was down-regulated in laryngeal squamous carcinoma tissues and negatively correlated with Methyl-CpG-binding protein 2 (MeCP2).

Source: Human Pathology - February 12, 2018 Category: Pathology Authors: Yafang Liu, Kai Chang, Kexin Fu, Xinjie Dong, Xiaoshuai Chen, Jixuan Liu, Ni Cui, Jinsong Ni Tags: Original contribution Source Type: research