Resistance Patterns of Enterobacteriaceae in Urines are Similar in Symptomatic and Asymptomatic Patients
Publication date: Available online 10 February 2018 Source:Journal of Hospital Infection Author(s): Alberto Romero Palacios, Fahad AL. dhufairi, Chelsey Ellis, Daniel Smyth, Lorraine Maze Dit Mieusement, Allison McGeer, Dominik Mertz Antibiograms of urine cultures are being used to guide empiric treatment for urinary tract infections (UTI). However, roughly 50% of urine cultures are from patients with asymptomatic bacteriuria (ABU). It is unclear whether enterobacteriaceae in ABU patients have similar resistance patterns as UTI patients. Hence, we aimed to compare the antimicrobial resistance patterns in patients with ABU to patients with symptomatic UTI. We found no major differences in resistance patterns, and therefore, empiric treatment choices can be guided by antibiograms that include ABU patients.
To evaluate how previous antimicrobial resistance, prior prescription data and patient place of residence (ZIP code) can guide empiric therapy for uncomplicated urinary tract infections (UTI).Guidelines recommend empiric antimicrobial selection for women with symptoms of uncomplicated UTIs, most commonly trimethoprim-sulfamethoxazole (SXT), nitrofurantoin (NIT) or ciprofloxacin (CIP). Previous antimicrobial resistance and prior prescription data are potential predictors of resistance in subsequent urine cultures for UTIs.
The FDA today approved Fetroja (cefiderocol), an antibacterial drug for treatment of patients with complicated urinary tract infections (cUTI), including kidney infections caused by susceptible Gram-negative microorganisms, who have limited or no alternative treatment options.
Conclusions: Due to high rates of resistance, strategies using empirical therapy of second-generation cephalosporins and fluoroquinolones should be reconsidered in this population. PMID: 31717981 [PubMed - in process]
ConclusionsImipenem-relebactam demonstrated potent in vitro activity against NPE and P. aeruginosa isolates from IAIs and UTIs, including against resistant subsets, and will provide important coverage for IAIs and UTIs caused by β-lactam-resistant, MDR, and KPC-positive Gram-negative bacilli.
Publication date: Available online 1 November 2019Source: Journal of Global Antimicrobial ResistanceAuthor(s): Madeline DeMarsh, P. Brandon Bookstaver, Caroline Gordon, Juanne Lim, Nicole Griffith, Nicole K. Bookstaver, Julie Ann Justo, Joseph Kohn, Majdi N. Al-Hasan, the Prisma Health Antimicrobial Stewardship and Support Team (PHASST)AbstractObjectiveThe study aims to predict resistance to sulfamethoxazole/trimethoprim (SXT) in patients with community-onset urinary tract infections (UTIs) due to Enterobacteriaceae based on patient-specific risk factors.DesignRetrospective case-control study.SettingPrisma Health facilitie...
Abstract Urinary tract infections caused by the bacteria Escherichia coli are among the most frequently encountered infections and a common reason for antimicrobial prescriptions. Resistance to fluoroquinolone antimicrobials, and in particular ciprofloxacin, has increased in recent decades. It is intuitive that variation in resistance is driven by changes in antimicrobial use, but careful study of this association requires the use of time-series methods. We studied seasonal variation in ciprofloxacin, trimethoprim-sulfamethoxazole, and ampicillin resistance in community-acquired urinary E. coli isolates in Montrea...
ConclusionThese results provide knowledge of the phylogenetic relationships of E. coli from bacteraemia in Ecuadorian patients. ST131 has emerged in ESBL-Ec, representing an important public-health problem because this multiresistant clone is considered to be a vehicle for the propagation of antimicrobial resistance genes and is a highly virulent, well-adapted human pathogen.
Conclusion: Elderly populations with diabetes are at a higher risk of UTI. Higher biofilm production and resistance to in-use antimicrobial agents in this study render its inefficacy for empirical treatment and point out the importance of biofilm screening to ensure the effective management of infection. PMID: 31641666 [PubMed - in process]
ConclusionThe draft genome sequence of this CRPA isolate could provide a solid basis for further research on the resistance mechanisms and the development of drug therapy for drug resistance genes.
ConclusionsC-T had potent activity against P. aeruginosa isolated from patients in hospitals in 4 continents. C-T was more active than all comparators, except COL, and maintained activity against MDR and XDR isolates and isolates non-susceptible to all 4 tested BLs. C-T was active against 12/16 COL-NS isolates.