Hollow PtPdRh Nanocubes with Enhanced Catalytic Activities for In Vivo Clearance of Radiation ‐Induced ROS via Surface‐Mediated Bond Breaking

Abstract
Catalytic nanomaterials can be used extrinsically to combat diseases associated with a surplus of reactive oxygen species (ROS). Rational design of surface morphologies and appropriate doping can substantially improve the catalytic performances. In this work, a class of hollow polyvinyl pyrrolidone‐protected PtPdRh nanocubes with enhanced catalytic activities for in vivo free radical scavenging is proposed. Compared with Pt and PtPd counterparts, ternary PtPdRh nanocubes show remarkable catalytic properties of decomposing H2O2 via enhanced oxygen reduction reactions. Density functional theory calculation indicates that the bond of superoxide anions breaks for the energetically favorable status of oxygen atoms on the surface of PtPdRh. Viability of cells and survival rate of animal models under exposure of high‐energy γ radiation are considerably enhanced by 94% and 50% respectively after treatment of PtPdRh nanocubes. The mechanistic investigations on superoxide dismutase (SOD) activity, malondialdehyde amount, and DNA damage repair demonstrate that hollow PtPdRh nanocubes act as catalase, peroxidase, and SOD analogs to efficiently scavenge ROS.

Hollow PtPdRh nanocubes function as superoxide dismutase, peroxidase, and catalase analogs and possess high catalytic activities to scavenge free radicals induced by high‐energy radiation, which is demonstrated by physicochemical characterization and density functional theory calculation. Moreover, in vitro and in viv...

Source: Small - February 9, 2018 Category: Nanotechnology Authors: Jun ‐Ying Wang, Xiaoyu Mu, Yonghui Li, Fujuan Xu, Wei Long, Jiang Yang, Peixian Bian, Junchi Chen, Lufei Ouyang, Haile Liu, Yaqi Jing, Jingya Wang, Lingfang Liu, Haitao Dai, Yuanming Sun, Changlong Liu, Xiao‐Dong Zhang Tags: Full Paper Source Type: research