SIRT1/FoxO3 axis alteration leads to aberrant immune responses in bronchial epithelial cells

In conclusion, CSE impairs the function of SIRT1/FoxO3 axis in bronchial epithelium, dysregulating NF‐κB activity and inducing pro‐inflammatory responses.

Source: Journal of Cellular and Molecular Medicine - February 7, 2018 Category: Molecular Biology Authors: Serena Di Vincenzo, Irene H. Heijink, Jacobien A. Noordhoek, Chiara Cipollina, Liboria Siena, Andreina Bruno, Maria Ferraro, Dirkje S. Postma, Mark Gjomarkaj, Elisabetta Pace Tags: Original Article Source Type: research