Pre-operative localization of abnormal parathyroid tissue by 99m Tc-sestamibi in primary hyperparathyroidism using four-quadrant site analysis: an evaluation of the predictive value of vitamin D deficiency

AbstractContextAccurate preoperative localization of abnormal parathyroid tissue aids importantly in minimally invasive parathyroidectomy in patients with primary hyperparathyroidism. Vitamin D deficiency may possibly influence the success and characteristics of pre-operative localization because it is associated with more active disease and possibly larger adenomas. This could increase the sensitivity of the sestamibi to identify abnormal parathyroid tissue, but earlier reports are conflicting. Vitamin D deficiency could also influence the nature of preoperative localization because it could lead to multi-gland stimulation of parathyroid tissue giving an appearance of multi-gland disease, which may lower accuracy of preoperative localization with sestamibi.ObjectiveTo examine the relationship between vitamin D deficiency and correct parathyroid tissue localization by four-pole thyroid quadrant analysis.DesignRetrospective study.SettingReferral center.ParticipantsA total of 138 patients were divided into three groups according to the level of 25OHD;
Source: Endocrine - Category: Endocrinology Source Type: research

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CONCLUSION: According to the results obtained, females and patients undergoing treatment with apixaban presented lower haemorrhagic risk, although there are doubts about whether this better safety profile is related to underdosing, which could influence its effectiveness. Therefore, these results should be analysed with caution and further studies are needed to confirm this data. PMID: 30503070 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
Authors: Gullón A, Sánchez Fuentes D, López-de-Sá E, Martí-Almor J, Barón-Esquivias G, Jiménez López J, Del Mar Contreras Muruaga M, Suárez Fernández C Abstract The present article provides an update on anticoagulant treatment in patients with atrial fibrillation in distinct clinical scenarios requiring particular considerations, such as ischaemic heart disease, electrical cardioversion, pulmonary vein ablation, the presence of valvular disease with or without prosthetic valves, and renal insufficiency, as well as old age and frailty. In patients...
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
Publication date: 2017Source: Journal of the American College of Clinical Wound Specialists, Volume 9, Issues 1–3Author(s): Richard Simman
Source: Journal of the American College of Clinical Wound Specialists - Category: General Medicine Source Type: research
Up to 50% of young women may be deficient in this vitamin. → Enjoying these psych studies? Support PsyBlog for just $4 per month (includes ad-free experience and more articles). → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: NEW: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Depression Nutrition Source Type: blogs
In conclusion, this is the first report to show that pyroptotic cell death occurs in the aging brain and that the inflammasome can be a viable target to decrease the oxidative stress that occurs as a result of aging. Reducing Levels of Protein Manufacture Slows Measures of Aging in Nematodes Researchers here demonstrate that an antibiotic slows aging in nematode worms, providing evidence for it to work through a reduction in protein synthesis. Beyond a slowing of aging, one of the con...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 8 December 2018Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Antonio Neme, Sabine Seuter, Marjo Malinen, Tarja Nurmi, Tomi-Pekka Tuomainen, Jyrki K. Virtanen, Carsten CarlbergAbstractIn the vitamin D intervention study VitDbol (NCT02063334) blood samples were drawn directly before an oral bolus (2000 µg vitamin D3) and 24 h later. The focus of phase II of VitDbol was the transcriptome-wide analysis of the effects of vitamin D gene expression in human peripheral blood mononuclear cells (PBMCs). All five participants responded in an individu...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
(Natural News) Taking vitamin A is not just good for improving and maintaining your eyes. It brings a host of health benefits involving many other important parts of the body. An article in Life Force Homeopathy even dubbed it the “angel vitamin” because it can keep you looking and feeling young. This underrated nutrient spurts...
Source: - Category: Consumer Health News Source Type: news
(Natural News) The adage “An apple a day keeps the doctor away” may hold some truth, but not in the way you expect. Surely, eating the flesh of an apple gives you plenty of nutrients, not the least of which are vitamin C and potassium, but studies suggest that eating the peel could give you additional...
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BEST supplements for tiredness: A combination of long hours at work, poor sleep habits, eating the wrong foods, and a mixture of poor diet and lifestyle habits can leave you feeling low on energy. Some experts believe taking a vitamin or mineral supplement could help give you the boost you need.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
In this study, we have generated and characterised congenic mice that contain the BALB/c SuprMam1 (susceptibility) locus on a C57BL/6 (resistant) background and discovered a subtle impairment in the vitamin D/ calcium/ parathyroid hormone (PTH) pathway. This was evident as altered gene expression in the mammary glands of key players in this pathway. Further functional analysis of the mice revealed elevated PTH levels, reduced Cyp27b1 expression in kidneys, and reduced trabecular bone volume/ tissue volume percentage. Plasma 25(OH)D and serum calcium were unchanged. This impairment was a result of genetic differences and oc...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
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