Anti-myelin oligodendrocyte glycoprotein (MOG) antibodies in patients with optic neuritis and seizures

We describe four patients who experienced optic neuritis (ON) and seizures and were found to have antibodies to myelin oligodendrocyte glycoprotein (MOG) in serum. The index case was a previously healthy 39-year-old man who developed steroid dependent ON and had a generalized seizure when steroids were tapered. He tested positive for antibodies to MOG. We have reviewed the charts of all 11 anti-MOG antibody positive patients in our practice and found that 4 patients, all of whom had experienced one of more episodes of ON, also had a generalized seizure during the course of their illness.

Source: Journal of the Neurological Sciences - February 3, 2018 Category: Neurology Authors: Josef Maxwell Gutman, Mark Kupersmith, Steven Galetta, Ilya Kister Tags: Clinical Short Communication Source Type: research