Breast Cancer Treatment Can Be Tough on the Heart

Title: Breast Cancer Treatment Can Be Tough on the HeartCategory: Health NewsCreated: 2/1/2018 12:00:00 AMLast Editorial Review: 2/2/2018 12:00:00 AM
Source: MedicineNet Cancer General - Category: Cancer & Oncology Source Type: news

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Authors: Cetintas S, Tezcan G, Tunca B, Egeli U, Gokgoz MS, Cecener G Abstract Distant organ tumor dissemination is a major cause of breast cancer-related deaths. In 2010, we analyzed the prognostic importance of the circulating tumor markers (CTM) cytokeratin (CK)19, CK20, epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) in relation to the clinical and pathological characteristics of patients with breast cancer (BC). To assess the clinical utility of CK19, CK20 and EGFR in predicting distant metastasis and recurrence in BC, here we report 7-year follow-up results of 77 pa...
Source: Bosnian Journal of Basic Medical Sciences - Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research
Authors: Kim DH, Yoon HJ, Cha YN, Surh YJ Abstract Cancer stem cells (CSCs) constitute a subpopulation of transformed cells that possess intrinsic ability to undergo selfrenewal and differentiation, which drive tumour resistance and cancer recurrence. It has been reported that CSCs possess enhanced protection against oxidative stress induced by reactive oxygen species compared with nonstem-like cancer cells. In the present work, we investigated the role of heme oxygenase-1 (HO-1), a representative antioxidant enzyme, on the stemness and selfrenewal of human breast CSCs. We found that pharmacologic or genetic inhibi...
Source: Free Radical Research - Category: Research Tags: Free Radic Res Source Type: research
Conclusion: MDM2 amplification was most commonly associated with liposarcoma. Concomitant alterations in additional genes such as CDK4 amplification and TP53 mutations, along with variable responses to targeted therapies including MDM2 inhibitors, suggest that further combinational studies are needed to target this population. PMID: 30237864 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Sahoo M, Katara GK, Bilal MY, Ibrahim SA, Kulshrestha A, Fleetwood S, Suzue K, Beaman KD Abstract The interaction of recruited immune effector cells and cancer cells within tumor microenvironment (TME) shapes the fate of cancer progression and metastasis. Many cancers including breast cancer, express a specific vacuolar ATPase (a2V) on their cell surface which acidifies the extracellular milieu helping cancer cell proliferation and metastasis. To understand the role of immune cell-associated-a2V during breast tumor pathogenesis, we knocked-out a2V (KO) from the hematopoietic stem cells (HSC) and generated ...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
In conclusion our results determined that ATX and SDC4 are engaged in a reciprocal collaboration for cancer cell metastasis providing the rational for the development of novel anti-metastasis therapies. PMID: 30237860 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
This study also demonstrated that the soft tissue thickness was higher in the affected arm and ultrasonographic findings were consistent with the other measurement methods (circumferences and limb volumes). Considering that ultrasound imaging is patient-friendly, non-invasive, and cost-effective, we recommend its more widespread use for evaluating treatment efficacy in BCRL. PMID: 30234245 [PubMed]
Source: Lymphology - Category: Internal Medicine Tags: Lymphology Source Type: research
Authors: Mayrovitz HN, Yzer JA Abstract Based on preliminary observations that topical cooling appeared to soften lymphedematous and fibrotic tissue, our goal was to systematically and quantitatively evaluate this effect. For this purpose, topical cooling was used as part of treatment of lymphedematous and fibrotic skin of women with breast cancer related lymphedema (BCRL) and localized fibrosis. Skin tissue hardness was assessed via the force required to indent skin to 4 mm (F4.0) and 1.3 mm (F1.3) and skin water was assessed by measurements of tissue dielectric constant (TDC). Measurements were done before coolin...
Source: Lymphology - Category: Internal Medicine Tags: Lymphology Source Type: research
Conclusions: We found that several conserved tumor stromal genes might regulate breast cancer invasion through ECM remodeling. The clinical outcome analyses of COL1A1 and FN1 suggest these two genes are promising targets for future studies. PMID: 30237810 [PubMed - in process]
Source: Cellular and Molecular Biology Letters - Category: Biochemistry Authors: Tags: Cell Mol Biol Lett Source Type: research
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Qiao-Ling Hu, Pei-Qian Wu, Ying-Hong Liu, Feng-Ming Qi, Chun-Xue Yu, Ye Zhao, Yi-Fan Yu, Dong-Qing Fei, Zhan-Xin ZhangAbstractThree new sesquiterpene lactones, 5α-hydroxy-4α,15-epoxy-11αH-eudesman-12,8β-olide (1), carabrol-4-O-palmitate (2) and carabrol-4-O-linoleate (3), along with five known ones, were isolated from the whole plant of Carpesium abrotanoides. The structures of new compounds were determined by extensive spectroscopic analysis, and compound 1 was also elucidated by X-ray single-crystal diffraction analys...
Source: Phytochemistry Letters - Category: Chemistry Source Type: research
Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Moustafa T. Gabr, Mohammed S. Abdel-RaziqAbstractNew series of arylsparteine derivatives were synthesized and evaluated for their cytotoxic activity against four human cancer cell lines (cervical epithelial carcinoma cells Hela, breast cancer cells MCF-7, lung cancer cells A549, and glioma cells U87 MG) and one normal fibroblast cell line. Structure-activity relationship revealed that introduction of 4-quinolinyl moiety to sparteine afforded a hybrid compound 10 with considerable antiproliferative activity against all tested cancer cell lines...
Source: Phytochemistry Letters - Category: Chemistry Source Type: research
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