Correspondence Challenges of measuring the Healthcare Access and Quality Index

We read with interest the GBD 2015 Healthcare Access and Quality study (July 15, 2017, p 231),1 which constructed the Healthcare Access and Quality (HAQ) Index on the basis of risk-standardised cause-specific death rates to facilitate comparisons of personal health-care access and quality for 195 countries and territories from 1990 to 2015. However, we would like to contest some of the findings on the HAQ Index related to chronic kidney disease (CKD).
Source: LANCET - Category: General Medicine Authors: Tags: Correspondence Source Type: research

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CONCLUSIONS: This is the first study providing clinical evidence on the use of PF-BES in all-comer patients irrespective of HBR status. Our findings suggest that PF-BES has a favorable safety and efficacy profile in a real world clinical setting. Further investigation in randomised clinical trials against new-generation DES is warranted. PMID: 29784631 [PubMed - as supplied by publisher]
Source: EuroIntervention - Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research
Abstract Chronic kidney disease affects approximately 10% of the world's adult population: it is within the top 20 causes of death worldwide, and its impact on patients and their families can be devastating. World Kidney Day and International Women's Day in 2018 coincide, thus offering an opportunity to reflect on the importance of women's health and specifically women's kidney health on the community and the next generations, as well as to strive to be more curious about the unique aspects of kidney disease in women so that we may apply those learnings more broadly. Girls and women, who make up approximately 50% ...
Source: Braz J Med Biol Res - Category: Research Authors: Tags: Braz J Med Biol Res Source Type: research
Conclusions ISCHEMIA will provide new scientific evidence regarding whether an invasive management strategy improves clinical outcomes when added to optimal medical therapy in patients with SIHD and moderate or severe ischemia.
Source: American Heart Journal - Category: Cardiology Source Type: research
AbstractPurposeAdiponectin an adipokine, produced by mature adipocyte, has an important effect on several aspects of endothelial function, including leukocyte adhesion (mediated by adhesion molecules like intercellular adhesion molecule 1 (ICAM1) endothelial cell selective adhesion molecule ESAM). Recently, it has been linked to vascular endothelial growth factor (VEGF)-modulated angiogenesis. ESAM might also be involved in modulating VEGF-dependent actions. We studied relationship of adiponectin to ESAM, ICAM1, and VEGF in type 2 diabetic patients (T2DP) with or without microvascular complications.MethodsIncident T2DP ref...
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research
Authors: Carfagna F, Del Vecchio L, Pontoriero G, Locatelli F Abstract INTRODUCTION: Hyperphosphatemia is common in late stages of chronic kidney disease and is often associated with elevated parathormone levels, abnormal bone mineralization, extra-osseous calcification, and increased risk of cardiovascular events and death. Several classes of oral phosphate binders are available to help control plasma phosphorus levels. Although effective at lowering serum phosphorus, they all have safety, tolerability, and compliance issues that need to be considered when selecting which one to use. Areas covered: This paper revi...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Endosc Int Open 2018; 06: E694-E699 DOI: 10.1055/a-0599-6085 Background/aims The rate of recurrent small-bowel bleeding (SBB) remains high despite the advent of balloon assisted enteroscopy (BAE). The study aims were to determine: (1) the diagnostic and therapeutic yields, and adverse event rate of repeat BAE in SBB, and (2) the predictors of a positive repeat BAE. Methods A retrospective review of a BAE database was conducted. Patients who had> 1 BAE for SBB were included. Primary outcomes were diagnostic yield, therapeutic yield, and adverse events of repeat BAE. Secondary outcomes were predictors of...
Source: Endoscopy International Open - Category: Gastroenterology Authors: Tags: Original article Source Type: research
In conclusion, RT was effective in reducing fibrosis and inflammation, in addition to increasing muscle strength and creatine kinase levels, in rats with CKD, independent of muscle mass.
Source: Life Sciences - Category: Biology Source Type: research
CONCLUSION: The cardiological societies' recommendation that patients with atrial fibrillation should be given oral anticoagulant drugs applies to the majority of such patients who also have chronic kidney disease. PMID: 29789105 [PubMed - in process]
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
Authors: Akiyama K, Kimura T, Shiizaki K Abstract Calciprotein particles (CPPs) are a new biological marker of chronic kidney disease-mineral and bone disorder (CKD-MBD). CPPs consist of phosphate, calcium, and some proteins, with phosphate being the major contributor to the level and biological activity of CPPs. Recent studies have shown the physiological and pathological significance of CPPs, including contributions to bone and mineral metabolism, and to tissue and organ impairments such as cardiovascular damage and inflammatory responses. These actions are well known as important aspects of CKD-MBD. Fibroblast g...
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
Condition:   Dwarfism Intervention:   Drug: Recombinant Human Growth Hormone Injection (rhGH) Sponsors:   GeneScience Pharmaceuticals Co., Ltd.;   Children's Hospital of Fudan University;   Beijing Children's Hospital;   Children's Hospital of Shanghai;   Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine;   The Children's Hospital, Zhejiang University S chool Of Medicine;   Children's hospital capital institute of pediatrics;   Peking University First Hospital;   Fu...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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