Advances in nanostructure-mediated hyperthermia in tumor therapies.

Advances in nanostructure-mediated hyperthermia in tumor therapies. Curr Drug Metab. 2018 Jan 29;: Authors: Dou JP, Zhou QF, Liang P, Yu J Abstract Hyperthermia has been proposed as a promising treatment modality for its advantageous profiles such as mini/non-invasiveness, good tolerability, and cost-effectiveness. Quick development of nanotechnology in recent years has greatly broadened the application area of hyperthermia and endowed it with attractive new functions. Thermal sensitive nanostructures can absorb energy from an external source. They can control the therapeutic heating only in the targeted region without damage to normal tissues. They can also be loaded with therapeutic drugs and/or functionalized with imaging properties to construct multifunctional theranostic nanoplatforms. Significant breakthroughs have been yielded in this new field in recent years. In this review paper, we presented an overview of different nanostructures mediated hyperthermia in terms of external stimuli source, mainly focusing on the recent advances in this field. Different kinds of recently reported thermal sensitizer, imaging guidance modality, or combined therapies have been briefly elucidated. Persisting challenges in current nanostructures mediated hyperthermia were also discussed. PMID: 29380691 [PubMed - as supplied by publisher]
Source: Current Drug Metabolism - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Metab Source Type: research