Proliferation-associated miRNAs-494, -205, -21 and -126 detected by in situ hybridization: expression and prognostic potential in breast carcinoma patients.

CONCLUSIONS: The present paper reports for the first time on the prognostic value of miRNA-494 in invasive breast cancer. Particularly, detection of miRNA-494 could benefit patients with node-negative breast cancer in identifying subgroups with aggressive disease. Based on our experience, the developed automatic ISH method to visualize altered levels of miRNAs-494, -205, -21 and -126 could be applied to routine pathology diagnostics providing that conditions of tissue treatment, especially fixation delays, are managed. PMID: 29362919 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29362919?dopt=Abstract

Source: Clinical Breast Cancer - January 23, 2018 Category: Cancer & Oncology Authors: Gurvits N, Autere TA, Repo H, Nykänen M, Kuopio T, Kronqvist P, Talvinen K Tags: J Cancer Res Clin Oncol Source Type: research