The nuclear receptor CAR / NR1I3 enhances the pro‐fibrotic effects of TGF‐β and contributes to the development of experimental dermal fibrosis

Conclusion: CAR is upregulated in SSc and regulates TGF‐β signaling. Activation of CAR increases the profibrotic effects of TGF‐β in cultured fibroblasts and in different preclinical models of SSc. Thus, inactivation of CAR might be a novel approach to target aberrant TGF‐β signaling in SSc and in other fibrotic diseases. © 2014 American College of Rheumatology.

Source: Arthritis and Rheumatism - August 22, 2014 Category: Rheumatology Authors: Jérôme Avouac, Katrin Palumbo‐Zerr, Nadira Ruzehaji, Michal Tomcik, Pawel Zerr, Clara Dees, Alfiya Distler, Christian Beyer, Holm Schneider, Oliver Distler, Georg Schett, Yannick Allanore, Jörg H.W. Distler Tags: Full Length Source Type: research