Chromosomal instability drives metastasis through a cytosolic DNA response

Chromosomal instability drives metastasis through a cytosolic DNA responseChromosomal instability drives metastasis through a cytosolic DNA response, Published online: 17 January 2018; doi:10.1038/nature25432In chromosomally unstable tumour cells, rupture of micronuclei exposes genomic DNA and activates the cGAS–STING cytosolic DNA-sensing pathway, thereby promoting metastasis.

Source: Nature AOP - January 17, 2018 Category: Research Authors: Samuel F. Bakhoum Bryan Ngo Ashley M. Laughney Julie-Ann Cavallo Charles J. Murphy Peter Ly Pragya Shah Roshan K. Sriram Thomas B. K. Watkins Neil K. Taunk Mercedes Duran Chantal Pauli Christine Shaw Kalyani Chadalavada Vinagolu K. Rajasekhar Giulio Genov Source Type: research