Orthosiphon stamineus (Misai Kucing) ameliorated postmenopausal osteoporosis in rat model

This study investigated the potential use of OS leaf extracts to ameliorate osteoporosis in ovariectomized rats.Methods:Fifty-six female Sprague-Dawley rats were randomly allocated into eight groups (n = 7): SHAM (healthy sham control); OVX (ovarietomized) nontreated rats (negative control); OVX + Remifemin (100 mg/kg body weight), and 2% green tea extract (positive controls); OVX + OS 50% ethanolic and aqueous extracts, both at either 150 or 300 mg/kg. After 16 weeks, the rats’ bones and blood were evaluated for osteoporosis indicators (protein and mRNA expressions), micro-computed tomography for bone histomorphometry, and three-point bending test for tibia mechanical strength.Results:The extracts dose-dependently and significantly (P 
Source: Menopause - Category: OBGYN Tags: Original Articles Source Type: research