The < b > < i > IL20 < /i > < /b > Genetic Polymorphism Is Associated with Altered Clinical Outcome in Septic Shock

Background: TheIL10 family of genes includes crucial immune regulators.We tested the hypothesis that single nucleotide polymorphisms (SNPs) inIL10,IL19,IL20, andIL24 of theIL10 family gene cluster alter the clinical outcome of septic shock.Methods: Patients with septic shock (n = 1,193) were genotyped for 13 tag SNPs ofIL10,IL19,IL20, andIL24.IL20 gene expression was measured in genotyped lymphoblastoid cells in vitro. Cardiac surgical ICU patients (n = 981) were genotyped forIL20 rs2981573 A/G. The primary outcome variable was 28-day mortality.Results: Patients with the G allele of IL20 rs2981573 had a significantly increased hazard of death over the 28-day period compared to patients with the A allele in the septic shock cohort (adjusted hazard ratio 1.27; 95% confidence interval 1.10-1.47;p = 8.0 × 10-4). Patients with the GG genotype had more organ dysfunction (p
Source: Journal of Innate Immunity - Category: Allergy & Immunology Source Type: research