Difficult to treat osteoarticulars infections : Focus on Mycobacterial and Fungal infection.
Difficult to treat osteoarticulars infections : Focus on Mycobacterial and Fungal infection. Acta Orthop Belg. 2017 Mar;83(1):110-123 Authors: Yombi JC, Seyler L, Cornu O, Barbier O, Libouton X, Rodriguez-Villalobos H, Thienpont E Abstract Bone and joint infections are rare but often devastating. While bacteria are most commonly encountered organisms, mycobacteria and fungi are less frequent. Management of the latter is often more complex, especially in the presence of foreign material. We will increasingly be faced with mycobacterial and fungal bone infections, as medical conditions and newer therapeutics lead to more immunosuppression. In this article, we will review osteomyelitis, septic arthritis and peri-prosthetic joint infections related to mycobacteria and fungi. PMID: 29322903 [PubMed - in process]
(Reuters) - An arthritis drug developed by Eli Lilly&Co and Incyte Corp should not be approved at a 4-milligram dose, advisers to the U.S. FDA voted on Monday, in a setback to the drugmakers that were counting on the treatment as a future blockbuster.
(Reuters) - A rheumatoid arthritis drug developed by Eli Lilly and Incyte Corp should not be approved at a higher dose, a U.S. Food and Drug Administration advisory committee voted on Monday, while backing the approval of a lower dose.
This study identified the factors that have an impact on RA drug treatment expenditure. Also, we showed that methods that enable extracting demographic and expenditure data of administrative information systems may represent important tools in the construction of economic studies to subsidize economic health evaluations, especially from the standpoint of the managers.
AbstractThe goals of this study were to determine if secretory sphingomyelinase (S-SMase) activity is elevated in patients with rheumatoid arthritis (RA) compared to control subjects and to examine the relationships of S-SMase activity with functional status, quality of life, and RA disease activity measurements. We collected data on 33 patients who were diagnosed with RA and 17 non-RA controls who were comparable in terms of age, sex, and race. Demographic, clinical data and self-reported measures of fatigue, pain, and physical function were obtained directly from patients and controls. RA patients also completed quantita...
AbstractThe study aims to analyse the clinical and immunological manifestations of paediatric antiphospholipid syndrome (APS) in patients, based on the 2006 revised classification criteria of definite APS. Fifty-eight paediatric patients with APS were enrolled and analysed retrospectively. A total of 37 female and 21 male patients with a mean age of 14 ± 3 years at disease onset were included. Fourteen (24%) cases were primary APS, and 40 (69%) cases were secondary to systemic lupus erythaematosus (SLE). Anti-nuclear antibody (ANA) positivity and hypocomplementemia were more common in secondary APS t...
AbstractAssessment of intracranial vessels includes transcranial Doppler (TCD). TCD performance requires intact temporal acoustic windows (TAW). Failure of TAW (TAWF) is present in 8 –20% of people. There have been no reports on TAWF in rheumatoid arthritis (RA). Altogether, 62 female RA patients were included. Among them, 20 were MTX-treated and biologic-free, 20 received infliximab, and 22 tocilizumab. The controls included 60 non-RA women. TAWF, temporal bone thickness, and texture were determined by ultrasound and CT. BMD and T-scores of multiple bones were determined by DEXA. Several bone biomarkers were assesse...
Roxanne Cooksey, a research fellow at Swansea University, explains the clearest ever evidence of a strong link between inflammatory conditions of the skin and bones, and heart woes.
Condition: Rheumatoid Arthritis Intervention: Diagnostic Test: Research new biomarker for RA Sponsor: Corporacion Parc Tauli Not yet recruiting
RHEUMATOID arthritis symptoms include joint pain, swelling and stiffness when someone is suffering from the condition. However, there are also a few early warning signs which, if detected, may help someone treat the condition earlier, reducing its severity.