Log in to search using one of your social media accounts:


MS Drug Ocrelizumab (Ocrevus) Approved in Europe MS Drug Ocrelizumab (Ocrevus) Approved in Europe

The European Commission clears the anti-CD20 monoclonal antibody for adults with relapsing multiple sclerosis and early primary progressive multiple sclerosis.International Approvals
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery News Alert Source Type: news

Related Links:

This article provides new information about multiple sclerosis (MS) using the 2010/2011 Neurological Conditions Prevalence File, the 2011/2012 Survey of Neurological Conditions in Institutions in Canada, and the 2011 Survey on Living with Neurological Conditions in Canada. An estimated 93,500 Canadians living in private households and 3,800 residents of long-term care institutions had been diagnosed with MS. Prevalence estimates were 159 and 418 cases per 100,000 population for men and women, respectively; 2.6 women reported MS for every man with the condition. Among the household population, MS was generally diagnosed bet...
Source: Health Reports - Category: International Medicine & Public Health Tags: Health Rep Source Type: research
Conditions:   Multiple Sclerosis;   Rehabilitation;   MRI Intervention:   Behavioral: Balance Training Sponsor:   Wayne State University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions from the literature are that larger studies are needed to confirm the exciting results from initial investigations before current trends in diffusion imaging can be translated to the neurology clinic. Also, for a comprehensive understanding of pathological processes, it is essential to take a multiple‐level approach, in which information at the micro‐, meso‐ and macroscopic scales is fully integrated. Diffusion in multiple sclerosis (MS) can provide information about the microstructure, but this might not be sufficient to explain clinical disability: the functional system impairment might emerge only whe...
Source: NMR in Biomedicine - Category: Radiology Authors: Tags: SPECIAL ISSUE REVIEW ARTICLE Source Type: research
We examined the transcriptional activation of the Klotho gene using three different systems: a Firefly luciferase (FLuc) and NanoLuc luciferase (NLuc) coincidence reporter system, a NLuc kn ock-in in Klotho 3′-UTR using CRISPR genomic editing, and two human cell lines: neuronal SY5Y cells and kidney HK-2 cells that express Klotho endogenously. The two sgRNAs enhanced Klotho expression at both the gene and protein levels. Our results show the feasibility of gene therapy for targeting Klotho using CRISPR technology. Enhancing Klotho levels has a therapeutic potential for increasing cognition and treating age-associated...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
The objective was to develop an evidence‐based clinical practice guideline for the pharmacological treatment of people with MS to guide healthcare professionals in the decision‐making process. MethodsThis guideline has been developed using the GRADE methodology and following the recently updated EAN recommendations for guideline development. Clinical questions were formulated in PICO format (patient, intervention, comparator, outcome) and outcomes were prioritized according to their relevance to clinical practice. An exhaustive literature search up to December 2016 was performed for each question and the evidence is pr...
Source: European Journal of Neurology - Category: Neurology Authors: Tags: EAN Guidelines/CME Article Source Type: research
CONCLUSIONS: The mean diameter of the jugular veins was 8.7 mm. Internal jugular veins with cylindrical morphology have a diameter smaller than other forms; this difference is statistically significant. The different morphology of the jugular vein confluence does not increase the possibility of a reflux because the positive Valsalva maneuvers are not statistically significant when compared to the various types. KEY WORDS: CCSVI, EchoColorDoppler Map, Jugulo-Subclavian Confluence Diameter. PMID: 29339583 [PubMed - in process]
Source: Annali Italiani di Chirurgia - Category: Surgery Tags: Ann Ital Chir Source Type: research
This study provides the largest and most comprehensive survey to-date of users of consumer tDCS devices. Obtaining a deeper knowledge of what drives home users—to purchase and use a consumer tDCS device (or for many, to cease to use it)—has important implications, both for ongoing debates about the ethical implications of the home use of tDCS, as well as for discussions of the regulation of direct-to-consumer neurotechnology. Thus, the present study not only provides an empirical foundation on which to base policy recommendations, but also offers a concrete, empirical perspective on a debate that has too-often ...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology brain-stimulation Consumer neurotechnology Direct-to-consumer neuroscience do it yourself Neuroethics non-invasive tDCS Transcranial-direct-current-stimulation Source Type: blogs
Marjan Gharagozloo, Katsiaryna V. Gris, Tara Mahvelati, Abdelaziz Amrani, John R. Lukens, Denis Gris
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Multiple sclerosis —MS. These two letters can change lives in an instant for young people starting out in their careers and family life. MS is hard to define, hard to treat, and hard to take. Yet over the past two decades, treatment has changed radically, from none to over a dozen disease modifying drugs that can re duce attack rate and mitigate disability. The 2017 revisions of the multiple sclerosis diagnostic criteria1 provide an opportunity for reflection.
Source: Lancet Neurology - Category: Neurology Authors: Tags: In Context Source Type: research
Bal ó’s concentric sclerosis (BCS) is a rare inflammatory demyelinating disorder of the central nervous system characterised by concentric layers of demyelination. It is unclear whether BCS is a variant of mult...
Source: Journal of Neuroinflammation - Category: Neurology Authors: Tags: Research Source Type: research
More News: Brain | Health | Multiple Sclerosis | Neurology | Neurosurgery