[Seminar] Thalassaemia

Inherited haemoglobin disorders, including thalassaemia and sickle-cell disease, are the most common monogenic diseases worldwide. Several clinical forms of α-thalassaemia and β-thalassaemia, including the co-inheritance of β-thalassaemia with haemoglobin E resulting in haemoglobin E/β-thalassaemia, have been described. The disease hallmarks include imbalance in the α/β-globin chain ratio, ineffective erythropoiesis, chronic haemolytic anaemia, co mpensatory haemopoietic expansion, hypercoagulability, and increased intestinal iron absorption.
Source: LANCET - Category: General Medicine Authors: Tags: Seminar Source Type: research