[Correspondence] Pitfalls of the healthy vaccinee effect – Authors' reply

In our Article,1 we presented findings from a case-control study that showed a protective effect of a meningococcal vaccine against gonorrhoea infection. In their Correspondence, Salaheddin Mahmud and Christiaan Righolt argue that the correct method to determine vaccine efficacy is a randomised controlled trial (RCT) and that our use of chlamydia as a control is problematic. We would like to clarify the points raised in their letter.

Source: LANCET - January 12, 2018 Category: General Medicine Authors: Helen Petousis-Harris, Janine Paynter, Jane Morgan, Peter Saxton, Felicity Goodyear-Smith, Steven Black Tags: Correspondence Source Type: research