In vitro antitubercular activity of extract and constituents from the stem bark of Disthemonanthus benthamianus

ABSTRACT A new C-glycosylflavone, apigenin 7-methyl ether 6-C-[ β -xylopyranosyl-(1 → 3)- β -glucopyranoside] named distemonanthoside was isolated from the stem bark of Distemonanthus benthamianus Baill., Fabaceae, along with six known compounds, sitosterol 3-O- β -D-glucopyranoside, 4-methoxygallic acid, syringic acid, quercetin, 6"-O-acetylvitexin, quercetin 3-O- β -D-glucopyranoside. The structures of those compounds and others were determined through spectral analyses. Compounds distemonanthoside, sitosterol 3-O- β -D-glucopyranoside, 4-methoxygallic acid and quercetin were tested against a clinical isolate strain of Mycobacterium tuberculosis AC 45; they exhibited good to moderate antitubercular activities with MIC values ranged from 31.25 to 125 µg/ml.
Source: Revista Brasileira de Farmacognosia - Category: Drugs & Pharmacology Source Type: research