Front cover story: Eur. J. Immunol. 1'18

Our front cover features an immunofluorescence staining of Bcl‐3 (red) and NF‐κB p50 (green) in psoriasis‐lesion skin. The image relates to the article by Tohyama et al. (pp. 168–179), where the authors show that Bcl‐3 enhances psoriasis‐related gene expression of epidermal keratinocytes in cooperation with p50. IL‐22 and IL‐17A, critical mediators in the pathogenesis of psoriasis, increase nuclear Bcl‐3 and p50 in epidermal keratinocytes. Bcl‐3 might be a future therapeutic target for the treatment of psoriasis.
Source: European Journal of Immunology - Category: Allergy & Immunology Tags: Cover Picture Source Type: research