Systemic IL ‐2/anti‐IL‐2Ab complex combined with sublingual immunotherapy suppresses experimental food allergy in mice through induction of mucosal regulatory T cells

In conclusion, the combination of two therapeutic strategies rendered Treg‐mediated tolerance more efficient compared to individual treatments and reversed the established IgE‐mediated food allergy. This approach highlights the ability of IL‐2C to expand Tregs, and it may represent a promising disease‐modifying therapy for managing food allergy. This article is protected by copyright. All rights reserved.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Fall.13402

Source: Allergy - January 10, 2018 Category: Allergy & Immunology Authors: Paola L. Smaldini, Fernando Trejo, Jos é L Cohen, Eliane Piaggio, Guillermo H. Docena Tags: Original Article: Experimental Allergy and Immunology Source Type: research