Preclinical validation of a targeted next generation sequencing-based comprehensive chromosome screening methodology in human blastocysts

This study is limited to whole chromosome aneuploidy, as mosaicism and segmental aneuploidy have not been investigated.WIDER IMPLICATIONS OF THE FINDINGSThese data show an accurate, high throughput method, and with the greater depth of each amplicon sequenced in comparison to commercial kits, there is greater application available for single nucleotide polymorphism based analysis for quality control.STUDY FUNDING/COMPETING INTERESTSThis study was funded through intramural research funds provided by the Foundation for Embryonic Competence. There are no competing interests.
Source: Molecular Human Reproduction - Category: Molecular Biology Source Type: research