Discovery of 4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.7b01339
Source: Journal of Medicinal Chemistry - Category: Chemistry Authors: Xueqing Wang, Bo Liu, Xenia Searle, Clinton Yeung, Andrew Bogdan, Stephen Greszler, Ashvani Singh, Yihong Fan, Andrew M Swensen, Timothy Vortherms, Corina Balut, Ying Jia, Kelly Desino, Wenqing Gao, Hong Yong, Chris Tse and Philip Kym Source Type: research
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