Bringing Renal Biopsy Interpretation Into the Molecular Age With Single-Cell RNA Sequencing

Summary: The renal biopsy provides critical diagnostic and prognostic information to clinicians including cases of acute kidney injury, chronic kidney disease, and allograft dysfunction. Today, biopsy specimens are read using a combination of light microscopy, electron microscopy, and indirect immunofluorescence, with a limited number of antibodies. These techniques all were perfected decades ago with only incremental changes since then. By contrast, recent advances in single-cell genomics are transforming scientists' ability to characterize cells.
Source: Seminars in Nephrology - Category: Urology & Nephrology Authors: Source Type: research