Precision Medicine for Acute Kidney Injury (AKI): Redefining AKI by Agnostic Kidney Tissue Interrogation and Genetics

Summary: Acute kidney injury (AKI) currently is diagnosed by a temporal trend of a single blood analyte: serum creatinine. This measurement is neither sensitive nor specific to kidney injury or its protean forms. Newer biomarkers, neutrophil gelatinase-associated lipocalin (NGAL, Lipocalin 2, Siderocalin), or kidney injury molecule-1 (KIM-1, Hepatitis A Virus Cellular Receptor 1), accelerate the diagnosis of AKI as well as prospectively distinguish rapidly reversible from prolonged causes of serum creatinine increase.

Source: Seminars in Nephrology - December 29, 2017 Category: Urology & Nephrology Authors: Krzysztof Kiryluk, Andrew S. Bomback, Yim-Ling Cheng, Katherine Xu, Pablo G. Camara, Raul Rabadan, Peter A. Sims, Jonathan Barasch Source Type: research