Low PIAS3 expression in malignant mesothelioma is associated with increased STAT3 activation and poor patient survival.

Conclusion: These results suggest that PIAS3 protein expression impacts survival in mesothelioma patients and that PIAS3 activation could become a therapeutic strategy. PMID: 25124686 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/25124686?dopt=Abstract

Source: Clinical Cancer Research - August 14, 2014 Category: Cancer & Oncology Authors: Dabir S, Kluge A, Kresak AM, Yang M, Fu P, Groner B, Wildey G, Dowlati A Tags: Clin Cancer Res Source Type: research