Biocatalytic reduction of activated CC-bonds and beyond: emerging trends.

Biocatalytic reduction of activated CC-bonds and beyond: emerging trends. Curr Opin Chem Biol. 2017 Dec 21;43:97-105 Authors: Winkler CK, Faber K, Hall M Abstract The biocatalytic reduction of activated CC-bonds is dominated by ene-reductases from the Old Yellow Enzyme family, which gained broad practical use owing to exquisite stereoselectivity combined with wide substrate scope. Protein diversity is fostered by mining distinct protein classes and by implementing protein engineering techniques. Recent efforts are focusing on expanding the chemical complexity of the product portfolio, either through substrate functionalization or design of multi-step reactions. This review also highlights unusual chemistries catalyzed by ene-reductases and presents emerging methodologies developed to bypass the need of natural nicotinamide cofactors. PMID: 29275291 [PubMed - as supplied by publisher]
Source: Current Opinion in Chemical Biology - Category: Biochemistry Authors: Tags: Curr Opin Chem Biol Source Type: research