Chemical constituents from leaves and root bark of Trichilia monadelpha (Meliaceae)

Publication date: February 2018 Source:Phytochemistry Letters, Volume 23 Author(s): Kemda Pamela Nangmo, Tontsa Armelle Tsamo, Liu Zhen, Pierre Mkounga, Sergi Herve Akone, Nole Tsabang, Werner E.G. Müller, Kirt Marat, Peter Proksch, Augustin Ephrem Nkengfack Two new limonoid derivatives designated, monadelphin A (1) and monadelphin B (2) and two new sesquiterpene derivatives named trichins A (3) and B (4) were isolated together with six known compounds (5–10) from the mixture of methylene chloride/methanol (1:1) extract of leaves and root bark of Trichilia monadelpha (Meliaceae) collected in Cameroon. The structures of the new compounds were unambiguously established by detailed spectroscopic analysis including 1D and 2D NMR data in conjunction with high resolution mass spectrometry data and by comparison of these data with those of related compounds described in the literature. Compounds 1–4 were screened for their cytotoxic potential. Compound 1 showed strong cytotoxicity against the mouse lymphoma L5178Y cell line with an IC50 value of 0.62μg/mL. The biogenetic origin of trichin B (4) from trichin A (3) was also postulated. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research