Short report: Follow ‐up of Bahamian women with a BRCA1 or BRCA2 mutation

ConclusionPreventive surgery is an acceptable option for a significant proportion of Bahamian women with a BRCA1 or BRCA2 mutation. It will be important to identify and reduce barriers to preventive surgery in the Bahamas in order that the benefit of getting testing can be fully realized. We sought to determine to what extent the knowledge of carrying a BRCA1 or BRCA2 mutation influences the uptake of preventive surgeries in Bahamian women. Of the 78 mutation carriers, 19 women had a bilateral salpingo‐oophorectomy (24%). Seven out of 37 patients who had unilateral breast cancer chose to remove the unaffected contralateral breast (19%) and three of 13 patients with no history of breast cancer chose to have a prophylactic bilateral mastectomy (23%).
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: CLINICAL REPORT Source Type: research

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Tara Huck, 34, had a mastectomy after her mother, aunt and grandmother were all diagnosed with breast cancer. Doctors believed an unidentified faulty gene could be responsible.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
We present, 5-year follow-up of QOL scores in breast cancer patients from India.MethodsWe interviewed women undergoing breast cancer surgery preoperatively, at 6  months after surgery, and at 1 year and 5 years, postoperatively. QOL scores were evaluated using FACT B questionnaire. Average QOL scores of women undergoing BCT were compared with those undergoing MRM. Total scores, domain scores and trends of scores over time were analyzed.ResultsWe interviewed 54 women with a mean age of 53  years (SD 9 ± years). QOL scores in all the women, dipped during the treatment period, in a...
Source: Quality of Life Research - Category: Health Management Source Type: research
After a Styles column about one woman ’s experience with an early diagnosis, readers shared poignant stories of fear and survival.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Breast Cancer Mastectomy Radiation Mammography Tamoxifen (Drug) New York Times Source Type: news
AbstractPurpose of ReviewPostmastectomy radiotherapy (PMRT) is often a component of treatment algorithms for locally advanced or node-positive breast cancer. Breast reconstruction may be delayed or not performed due to negative effects of PMRT on the reconstruction. Administering radiotherapy in the preoperative setting allows for immediate breast reconstruction (IBR) to be performed in patients who have indications for PMRT and desire IBR. This review summarizes the current literature on this new concept.Recent FindingsMost prospective treatment protocols included neoadjuvant systemic therapy followed by radiotherapy (RT)...
Source: Current Breast Cancer Reports - Category: Cancer & Oncology Source Type: research
(Wiley) A woman's decision to undergo mastectomy for breast cancer relies on communication with her surgeon and, in addition, often draws on recommendations from a 'multidisciplinary team' (MDT) of doctors from different specialties such as oncology and radiology. An analysis published in the BJS found that most mastectomies in the UK are advised when tumours are large, and that some of these might have been avoided if more women had been given hormone therapy or chemotherapy to shrink the cancer before the surgery.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
CONCLUSION: Most mastectomies are advised for large tumour to breast size ratio, but there is an inconsistency in the use of NST to downsize tumours in patients with large ER+ or HER2+ cancers. The application of standardized recommendations for NST could reduce the number of mastectomies advised by MDTs. PMID: 31691270 [PubMed - as supplied by publisher]
Source: The British Journal of Surgery - Category: Surgery Authors: Tags: Br J Surg Source Type: research
Abstract Management strategy of micro or macro metastatic sentinel lymph node(s) (SLNs) in breast cancer has dramatically changed over the past ten years and the publication of five randomized trials results: ACOSOG Z0011, IBCSG 23-01, and AATRM comparing axillary lymph node dissection (ALND) versus SLNs biopsy alone; and AMAROS and OTOASOR comparing ALND versus axillary radiotherapy. Despite methodological limitations of several of these trials, notably ACOSOG Z0011, the international recommendations (ASCO, NCCN) and the expert consensus of St Gallen do not recommend the performance of a complementary ALND in cas...
Source: Bulletin du Cancer - Category: Cancer & Oncology Authors: Tags: Bull Cancer Source Type: research
We report results of SSM with RLDFR, mainly ...
Source: World Journal of Surgical Oncology - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
The aim of this study was to assess the effect of preoperative sleep quality on acute postoperative pain in breast cancer patients. The Pittsburgh Sleep Quality Index questionnaire (PSQI) was used to assess the overall sleep status of women scheduled for unilateral modified radical mastectomy in the past month. Based on the responses, patients were allocated to good sleep group or poor sleep group. Postoperatively, acute pain was assessed using the numerical rating score in the first 24 hours; in addition, the requirement of analgesics and the incidence of postoperative complications were recorded. A total of 108 breas...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Conditions:   Breast Cancer;   Pain, Chronic;   Pain, Postoperative;   Mastectomy; Lymphedema Intervention:   Other: Rehabilitation protocol Sponsor:   University of Roma La Sapienza Completed
Source: - Category: Research Source Type: clinical trials
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