High-Intensity Exercise May Cut Parkinson's Motor Symptoms High-Intensity Exercise May Cut Parkinson's Motor Symptoms

Patients with de novo Parkinson's disease receiving high-intensity treadmill training had lower 6-month motor symptom scores than those receiving usual care, new research shows.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

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In conclusion, we focus on the various newer molecular mechanisms that are associated with the basic understanding of neuroinflammation in neurodegeneration.
Source: Neurochemistry International - Category: Neuroscience Source Type: research
Laura Avanzino, Mirta Fiorio, Antonella Conte
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Authors: Antonini A, Stoessl AJ, Kleinman LS, Skalicky AM, Marshall TS, Sail KR, Onuk K, Odin PLA Abstract BACKGROUND: Lack of a global consensus on definition of advanced Parkinson disease (APD) and considerations for timing of device-aided therapies may result in heterogeneity in care. OBJECTIVES: To reach consensus among movement disorder specialists regarding key patient characteristics indicating transition to APD and guiding appropriate use of device-aided therapies in the management of PD symptoms. METHODS: A Delphi-panel approach was utilized to synthesize opinions of movement disorder specialists a...
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Conclusion: Tensor decomposition is a useful method for the modeling and analysis of multisensor time series in patients with Parkinson's disease. Significance: Tensor-decomposition factors can be potentially used as physiological markers for Parkinson's disease, and effective features for machine learning that can provide early prediction of the disease progression.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Short α-synuclein peptide affects uptake of dopamine rather than forming typical clumps in the brain
Source: NanoFocus - Category: Nanotechnology Authors: Source Type: research
AbstractNeuropsychiatric symptoms are highly prevalent in Parkinson ’s disease and associated with decreased quality of life and adverse health outcomes. In this review, the assessment and management of common neuropsychiatric symptoms are discussed: depression, anxiety, psychosis, cognitive impairment, dementia and apathy. Validated assessment scales are now avai lable for the majority of symptoms. Balancing dopaminergic therapy plays an important role in their management as increasing doses of dopaminergic agents might address depression and anxiety related to ‘off’ phases, non-motor fluctuations and ap...
Source: CNS Drugs - Category: Neurology Source Type: research
AbstractThe interaction between adenosine A2A and dopamine D2 receptors in striatal neurons is a well-established phenomenon and has opened up new perspectives on the molecular mechanisms involved in Parkinson ’s disease. However, it has barely been investigated in astrocytes. Here, we show by immunofluorescence that both A2A and D2 receptors are expressed in adult rat striatal astrocytes in situ, and investigate on presence, function, and interactions of the receptors in the astrocyte processes—acute ly prepared from the adult rat striatum—and on the effects of homocysteine on the A2A-D2 receptor-recepto...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
19 –22 August 2018, Lyon, France
Source: Scientific and Medical Events on Global Events List - Category: Science Source Type: events
This study examines the therapeutic effects of transplantation of Nurr1 gene-modified bone marrow mesenchymal stem cells (MSCs) on 6-hydroxydopamine (6-OHDA)-induced PD rat models. MSCs were transduced with lentivirus expressing Nurr1 gene and then intrastriatally transplanted into PD rats. Our results showed that Nurr1 gene-modified MSCs overexpress and secrete Nurr1 protein in vitro and also survive and migrate in the brain. Four weeks after transplantation Nurr1 gene-modified MSCs dramatically ameliorated the abnormal behavior of PD rats and increased the numbers of tyrosine hydroxylase (TH)-positive cells in the substa...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
ConclusionsWe concluded that cognitive training along with active tDCS is a useful combined approach in the management of mood and cognitive dysfunctions in PD.
Source: Brain Stimulation - Category: Neurology Source Type: research
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