High-Intensity Exercise May Cut Parkinson's Motor Symptoms High-Intensity Exercise May Cut Parkinson's Motor Symptoms
Patients with de novo Parkinson's disease receiving high-intensity treadmill training had lower 6-month motor symptom scores than those receiving usual care, new research shows.Medscape Medical News
Even a mild brain injury may significantly increase risk, according to a new large study of U.S. veterans
CONCLUSIONS: The TUG, FTSTS and BMT were responsive to the GPTI and accurately detected meaningful clinical changes. Our results provide an important information about the clinical application of these tests in PD individuals. PMID: 29660960 [PubMed - as supplied by publisher]
CONCLUSION: The present findings demonstrate that gait training with a VR program is as effective as treadmill training with regard to gains in walking distance and improvements in temporal gait variables in individuals with PD. PMID: 29660956 [PubMed - as supplied by publisher]
CONCLUSIONS: We demonstrated that neuromuscular electrical stimulation applied to the infrahyoid region combined with effortful swallowing effectively increased hyoid bone movement and reduced aspiration in dysphagic patients with Parkinson's disease. PMID: 29660951 [PubMed - as supplied by publisher]
Authors: Gallastegui E, Domuro C, Serratosa J, Larrieux A, Sin L, Martinez J, Besson A, Morante-Redolat JM, Orlando S, Aligue R, Fariñas I, Pujol MJ, Bachs O Abstract Alpha-synuclein (α-SYN) is the main component of anomalous protein aggregates (Lewy bodies) that play a crucial role in several neurodegenerative diseases (synucleinopathies) like Parkinson's disease and multiple system atrophy. However, the mechanisms involved in its transcriptional regulation are poorly understood. We investigated here the role of the cyclin-dependent kinase (Cdk) inhibitor and transcriptional regulator p27Kip1 (p27) in...
(Reuters Health) - A new study of hundreds of thousands of U.S. armed forces veterans concludes that banging your head severely enough to lose consciousness can dramatically increase the risk of Parkinson's, the brain disease marked by tremors, slow movements, balance problems and difficulty walking.
OBJECTIVE: Excessive daytime sleepiness (EDS) is one of the most common sleep abnormalities in patients with Parkinson's disease (PD), yet its multifactorial etiology complicates its treatment. This review summarized recent studies on the epidemiology, eti...
This study aimed to identify features that may differentiate BP patients with and without neurologic disease. 105 patients with BP were enrolled in this study: 75 control BP patients with no neurologic disease (CON), 10 patients with BP and a prior diagnosis of Parkinson ’s disease (BP+PD), 11 BP with dementia patients (BP+DEM), and 9 BP with stroke (BP+STR).
This study utilised a mass spectrometry based proteomic approach to identify biomarkers of metastasis between primary cSCCs which had metastasised (P-M) and primary cSCCs which had not metastasised (P-NM). Tumour and surrounding immune infiltrate was microdisected from formalin fixed paraffin embedded (FFPE) samples before being subjected to liquid chromatography mass spectrometry using a Waters Nano Acquity HPLC coupled to a Synapt G2-Si high definition mass spectrometer.
The open access paper noted here reports on the use of a genetic analysis to shed further light on the relative importance of shared mechanisms across a range of neurodegenerative conditions in which tau aggregation is thought to be important. The researchers find associations in gene expression between these conditions that suggesting microglial dysfunction is an important common determinant of disease progression. If one looks over all of the most common neurodegenerative diseases, patients exhibit a number of overlapping mechanisms that appear plausible as proximate causes of brain cell dysfunction and death. Som...