Clinical implications of the deregulated TP73 isoforms expression in cancer

AbstractTP73 is a member of theTP53 family whose expression has been observed altered in most human cancers and associated with the prognosis.TP73 translates into a complex number of isoforms with both oncogenic and tumour-suppressor functions and presents a complex cross-talk with other members of the family (TP53 andTP63). In this revision, we focus on the evidence that may supportTP73 variants as prognostic markers in cancer. Nowadays, most publications in this topic highlight the association between overexpression of the oncogenic variants and failure to respond to chemotherapy and/or shorter survival. In addition, we comment on the putative possibilities that the detection through a liquid biopsy ofTP73 variants may provide, and finally, the significance of determining the value of the combined alteration of theTP53 family members in the clinical setting.
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research