Conserved Elements Vaccine for HIV

Researchers at the National Cancer Institute (NCI) have developed a DNA vaccine using conserved elements (CEs) of HIV-1 Gag, administered in a prime-boost vaccination protocol. Two of the HIV Gag CE DNA vectors have been tested in a rhesus macaque model. Priming with the Gag CE vaccine and boosting with full length Gag DNA showed increased immune responses when compared to vaccination with Gag alone. Researchers seek licensing and/or co-development research collaborations for development this DNA vaccine.NIH Ref. No.: E-132-2012Advantages: • Addresses two key hurdles faced by current HIV vaccines: sequence diversity of HIV and immunodominance.• Induces cross-clade cellular and humoral responses. Applications: • Prophylactic and therapeutic vaccines for HIV-1 infection Development Status: ClinicalUpdated On: Dec 7, 2017Provider Classifications: Date Published: Thursday, December 7, 2017Publications: Patent Application: PCT/US2013/028932EP2820035 A115/235,430Patent Number: 9,415,099Licensing Contacts: Lead Inventor: Inventor Lab URL: https://ccr.cancer.gov/Vaccine-Branch/george-n-pavlakishttps://ccr.cancer.gov/Vaccine-Branch/barbara-k-felberInv Is lead: LPM Phone: [phone]LPM Email: [e-mail] Classification: VaccinesDTDT Description: VaccinesPat Filing Date: 2013-03-04T00:00:002013-03-04T00:00:002016-08-12T00:00:00Patent Issue Date: 2016-08-16T00:00:00Pub...

Source: NIH OTT Licensing Opportunities - December 7, 2017 Category: Research Authors: ajoyprabhu3 Source Type: research