Gum infections tied to increased risk of stomach cancer precursor

(Reuters Health) - Gum infections may increase people ’s risk for sores in the digestive tract that can lead to stomach cancer, a small study suggests.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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Abstract Several microRNAs (miRNAs) have been reported as oncogenes or tumor suppressors in many cancers, including gastric cancer (GC). However, the role and molecular mechanism of miR-3129 in GC is largely unknown. We aimed to explore the function and the underlying molecular mechanism of miR-3129 in GC. Cancer tissues and corresponding adjacent tissues were collected from 50 patients with GC, and the expression of miR-3129 was detected by RT-qPCR. The expression of miR-3129 and pRb in human GC cell line SCG7091 was altered by transient transfection. Thereafter, MTT and flow cytometry assays were used to analyze...
Source: Braz J Med Biol Res - Category: Research Authors: Tags: Braz J Med Biol Res Source Type: research
AbstractThe aim of the present study was to investigate the expression of Forkhead box transcription M1 (FoxM1) and Forkhead box transcription P3 (FoxP3) in gastric cancer tissues in order to reveal any correlation between FoxM1, FoxP3 and clinicopathological parameters. Their clinical significance in gastric cancer was also investigated. Immunohistochemistry was used to detect the expression of FoxM1 and FoxP3 in gastric cancer and para-cancer tissues. The clinical significance of FoxM1 and FoxP3 in gastric cancer was explored, and the association between FoxM1 and FoxP3 was further analyzed. As a result, the overexpressi...
Source: Clinical and Experimental Medicine - Category: Research Source Type: research
Conditions:   Cervical Cancer;   Microsatellite Instability (MSI)-High Endometrial Cancer;   Gastric Cancer (Including Stomach and Gastroesophageal Junction [GEJ]);   Esophageal Cancer;   Hepatocellular Carcinoma;   Melanoma (Uveal Melanoma Excluded);   Merkel Cell Carcinoma;   Mesothelioma;   MSI-high Colorectal Cancer;   Non-small Cell Lung Cancer (NSCLC);   Ovarian Cancer;   Squamous Cell Carcinoma of the Head and Neck (SCCHN);   Small Cell Lung Cancer (SCLC); &n...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions Endoclot PHS represents a new alternative, complementary, and promising therapy for patients with an acute UGIB from a gastric malignancy. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text
Source: Endoscopy International Open - Category: Gastroenterology Authors: Tags: Original article Source Type: research
This study was designed to investigate the mechanism of AS-IV protecting gastric mucosa in N-methyl-N’-nitro-N-nitrosoguanidine (MNNG)-induced GPL rats. The lesions of GIM and GED were significantly ameliorated compared with the model rats, especially crowded tubular glandular and back-to-back tubular structure, which were the dangerous borderline between GPL and GC. Western Blot analysis showed that the ratio of Bcl-2/Bax and the protein expression of Bcl-XL, p53, Beclin1, p62, ATG5 and ATG12 were decreased and the level of Caspase3 was increased in the group of AS-IV compared with the model group; RT-PCR analysis s...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: August 2018 Source:Biomedicine & Pharmacotherapy, Volume 104 Author(s): Xiaocong Wang, Huihua Hu, Hebo Liu This work aims to explore the roles and related mechanisms of RNA binding protein Lin28B in gastric cancer cells stemness. We found that Lin28B expression was negatively correlated with the overall survival (OS) of gastric cancer patients, and significantly increased in gastric cancer cells compared with that in gastric epithelial cells. Lin28B overexpression increased spheroid formation, expression of gastric cancer stemness-related markers, and decreased cisplatin sensitivity in gastric cancer...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: 15 October 2018 Source:Sensors and Actuators B: Chemical, Volume 271 Author(s): Nicolò Landini, Gabriele Anania, Barbara Fabbri, Andrea Gaiardo, Sandro Gherardi, Vincenzo Guidi, Giorgio Rispoli, Lucia Scagliarini, Giulia Zonta, Cesare Malagù Nowadays, the demand for devices capable of efficiently identifying the presence of various biomarkers in human body, connected to a wide variety of pathologies, is progressively increasing. Chemoresistive semiconductor sensors, capable of changing their conductance depending on the chemical reactions between their surface and gaseous analytes, could be...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
CONCLUSION: Patients with classic variant of infiltrate lobular cancer of breast should be regularly follow-up, which could permit early diagnosis of distant metastases and improve treatment results. PMID: 29787007 [PubMed - in process]
Source: European Journal of Gynaecological Oncology - Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research
That’s a bold statement—eat until you’re satisfied—in a world in which just about every nutritional authority tells you the opposite. But conventional advice was created by the uninformed to deal with appetite-stimulating opiate effects from wheat and grains. Remove wheat and grains and appetite recedes dramatically and calorie intake drops off without effort. There will be no mad scrambles for food due to overwhelming hunger, no sneaking ice cream in the middle of the night, no hidden snacks around the house. No more anxiously counting minutes until lunch or dinner. There will be no rolling, rumbli...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle belly fat blood sugar cholesterol consuming fat Dr. Davis energy grain grain-free meat red meat undoctored Weight Loss Wheat Belly Total Health Source Type: blogs
Authors: Bozkaya Y, Erdem GU, Demirci NS, Yazıcı O, Özdemir NY, Köstek O, Zengin N Abstract AIM: The aim of this study was to evaluate the prognostic importance of albumin to globulin ratio (AGR) in terms of overall survival (OS) and progression free survival (PFS) in metastatic gastric cancer patients. METHODS: The patients diagnosed with metastatic gastric cancer between 2009 and April 2016 at our hospital have been studied retrospectively. The clinicopathological characteristics, laboratory and treatment parameters have been assessed. AGR value has been calculated using the following formula (AGR...
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
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