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Gum infections tied to increased risk of stomach cancer precursor

(Reuters Health) - Gum infections may increase people ’s risk for sores in the digestive tract that can lead to stomach cancer, a small study suggests.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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Authors: Xie JF, Xie NS, Tang JH, Gu QP, Luo QT Abstract OBJECTIVE: Previous studies showed the aberrant expression of Src homology 2-containing inositol 5-phosphatase 2 (SHIP2) in GC tissue. However, the exact role of circulating SHIP2 in GC remains unclear. The aim of this manuscript was to analyze potential diagnostic and prognostic value of circulating SHIP2 levels in GC. PATIENTS AND METHODS: Circulating SHIP2 expression was detected in the plasma of 156 GC patients and 60 healthy controls by qRT-PCR. The receiver operating characteristic (ROC) curves were plotted to explore the reliability of circulating ...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
CONCLUSIONS: MiR-582-5p exerted tumor-suppressive effects on gastric cancer growth via targeting AKT3 in vitro, which provided an innovative and candidate target for diagnosis and treatment of gastric cancer. PMID: 29228422 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
CONCLUSIONS: miR-377 expressed lower in GC and suppressed cell proliferation, migration and invasion partly via repressing the VEGFA expression, which could provide a potential target for GC diagnosis and therapy. PMID: 29228421 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
CONCLUSIONS: Highly expressed GHET1 promotes the proliferation of pancreatic cancer, inhibits apoptosis and is related to TNM staging. The expression of GHET1 can be used as a potential molecular marker for the prognosis and therapeutic target of pancreatic cancer. PMID: 29228419 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Authors: Kino H, Nakano M, Kanamori A, Suzuki T, Kaneko Y, Tsuchida C, Tsuchida K, Tominaga K, Sasai T, Yamagishi H, Imai Y, Hiraishi H Abstract A 78-year-old man underwent endoscopic submucosal dissection (ESD) for early gastric adenocarcinoma twice in 2009 and 2014. Between the procedures, he successfully completed Helicobacter pylori eradication therapy. In May 2015, upper endoscopy screening showed two elevated lesions on the gastric fundus, and en bloc resection by ESD was performed. We histopathologically diagnosed the patient to have gastric adenocarcinoma of the fundic gland type. In this case, the two lesi...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
We present the first case of E. tarda bacteremia with psoas and epidural abscess. The patient was a 65-year-old woman with recurrent gastric cancer who had frequently consumed raw fish and grilled eel. She was successfully treated with antimicrobials and surgery. We also review reports published in English regarding E. tarda bacteremia in Japan and the experience at our hospital. On the basis of this review, we conclude that the major underlying disease leading to E. tarda bacteremia is malignancy and that the gastrointestinal tract is the most commonly affected organ. The overall mortality rate due to E. tarda bacteremia ...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Pseudomesotheliomatous carcinoma is a malignant tumor that extends along the pleura mimicking malignant mesothelioma. An 81‐year‐old male patient presented to our hospital with epigastralgia, and abdominal computed tomography (CT) showed a 36‐mm tumor in the pancreatic tail. The laboratory data revealed a high leukocyte count (>44 000/μL). Chest CT showed left pleural thickening with pleural effusion. The cancer showed a poor response to chemotherapy, and the patient died of respiratory failure at 5 months after the onset of disease. Autopsy showed solid tumor with hemorrhage, measuring 6 cm in diameter, in the...
Source: APMIS - Category: Research Authors: Tags: Case Report Source Type: research
Gastric cancer is the third most common cause of cancer-related death worldwide,1 and most cases are locally advanced or metastatic at diagnosis. Widespread Helicobacter pylori eradication2 and radiologic or endoscopic screening,3 have been proved to decrease gastric cancer mortality in high-incidence countries. However, in countries with lower incidence, these strategies are probably not cost effective, and there are only recommendations regarding secondary prevention in high-risk patients, such as those with gastric preneoplastic conditions.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Original article Source Type: research
ConclusionsThe short-term results of the current study suggest that LAG with D2 lymph node dissection is a safe and feasible procedure in treating patients with locally AGC in experienced centers.
Source: Surgical Endoscopy - Category: Surgery Source Type: research
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
More News: Cancer | Cancer & Oncology | Gastric (Stomach) Cancer | Health | Study