Gum infections tied to increased risk of stomach cancer precursor
(Reuters Health) - Gum infections may increase people ’s risk for sores in the digestive tract that can lead to stomach cancer, a small study suggests.
Date: Wednesday, 03 21, 2018; Speaker: Charles Rabkin, M.D., Senior Investigator, Division of Cancer Epidemiology and Genetics, NCI; https://epi.grants.cancer.gov/events
Conclusion: We observed a high adherence to counselling, genetic testing and active surveillance by men belonging to hereditary BC families. Male carriers of pathogenic DNA variants are at risk for several cancers and should be included in prospective follow-up studies. PMID: 29456621 [PubMed]
Conclusion: The Mortality-Incidence Ratio complement [1 - MIR] is an appropriate tool for approximating observed five-year survival for the ten types of cancers studied. This study demonstrates the validity of this model for predicting five-year survival in cancer patients in metropolitan Lima. PMID: 29456616 [PubMed]
Authors: Bo X, Chen Y, Sheng W, Gong Y, Wang H, Gao W, Zhang B Abstract Gastric cancer is a major cause of cancer-associated mortality worldwide. The aberrant expression of microRNA (miRNA) is involved in tumorigenesis. Ras proteins transfer information from the extracellular environment to internal cellular compartments and are essential in numerous signal transduction pathways. To investigate the regulation, function and clinical significance of the miRNA377/Ras association domain family (RASSF) 8 signaling axis in gastric cancer, reverse transcription-quantitative polymerase chain reaction, immunohistochemistry,...
In this study, we utilized transcriptome sequencing (RNA-seq) methodology to compare the transcriptional profiles of H. pylori grown in media containing different concentrations of sodium chloride. We identified 118 differentially expressed genes (65 upregulated and 53 downregulated in response to high-salt conditions), including multiple members of 14 operons. Twenty-nine of the differentially expressed genes encode proteins previously shown to undergo salt-responsive changes in abundance, based on proteomic analyses. Real-time reverse transcription (RT)-PCR analyses validated differential expression of multiple genes enc...
If you’ve been following the Wheat Belly discussions, you already know that efforts to cultivate healthy bowel flora in the wake of wheat/grain elimination is a key factor in regaining health. While I’ve emphasized the importance of a high-potency (e.g., 50 billion or more CFUs per day), multi-species probiotic supplement and prebiotic fibers, I’ve not focused on the importance of fermented foods. This issue comes to light in particular with our experience in battling small intestinal bacterial overgrowth, or SIBO. Dysbiosis, or disrupted composition of bowel flora in the colon, is exceptionally common, e...
It has been suggested that nutritional status is related to the survival outcomes of cancer patients. The purpose of the current research is to evaluate the importance of the prognosis of various nutritional parameters during the perioperative period in patients with gastric cancer.
ConclusionsThis correlation implies that close and frequent monitoring of such high-risk patients is necessary to facilitate timely diagnosis of gastric cancer.
This study explored the cumulative incidence of anemia after gastrectomy in patients with early-stage gastric cancer and evaluated the relationship between postgastrectomy anemia and nutritional factors during long-term follow-up.
ConclusionsThe incidence of MGC after PG was significantly higher than that after DG. However, most of the MGCs that developed after PG could be treated by endoscopic submucosal dissection.