Gum infections tied to increased risk of stomach cancer precursor

(Reuters Health) - Gum infections may increase people ’s risk for sores in the digestive tract that can lead to stomach cancer, a small study suggests.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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ConclusionAll the data showed that high expression of ABL2 suppresses apoptosis through Ras/Erk and PI3K/AKT signaling pathway in GC cell lines.
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
Conclusion: our findings suggestedCAT rs769218 andGPx3 rs736775 may be considered as prognostic markers in gastric cancer. Patient stratification byGPx3 rs736775 and conventional pathological parameters may provide additional predictive information in treatment decision-making.Cell Physiol Biochem 2018;48:2247 –2257
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
Authors: Huang Y, Zhang J, Wang G, Chen X, Zhang R, Liu H, Zhu J Abstract Oxymatrine (OMT) as a type of alkaloids collected from Sophora flavescens Ait exerts some biological functions including anticancer properties. Here, we investigated the therapeutic effects of OMT in gastric cancer cells (HGC 27 and AGS). As a result, the exposure of gastric cancer (GC) cells to OMT contributed to the suppression of cell proliferation and invasion. Interleukin 21 receptor (IL-21R) was identified to be differentially expressed between OMT treatment group (4 mg/mL) and control group (0 mg/mL), and knockdown of IL-...
Source: International Journal of Immunopathology and Pharmacology - Category: Allergy & Immunology Tags: Int J Immunopathol Pharmacol Source Type: research
Authors: Chen H, Wang J, Zhuang Y, Wu H Abstract The genetic alterations in familial intestinal gastric cancer (FIGC) have not been clearly understood. Aiming to explore the molecular basis and the driving mutations underlying the pathogenesis of FIGC, we performed exome sequencing of the blood samples of the members of an extended family with FIGC. The differences in mutation patterns between family members with gastric cancer and controls were analysed and the overlapped variants were screened by comparing previously published data for blood and tumours from gastric cancer patients. The overlapped genes harb...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Netrin‑1 induces the proliferation of gastric cancer cells via the ERK/MAPK signaling pathway and FAK activation. Oncol Rep. 2018 Aug 01;: Authors: Yin K, Shang M, Dang S, Wang L, Xia Y, Cui L, Fan X, Qu J, Chen J, Xu Z Abstract Netrin‑1 (NTN1) has been demonstrated to promote tumorigenesis in multiple types of cancer; however, its role in the growth of gastric cancer (GC) cells has not been described in detail. In the present study, the data suggested that NTN1 knockdown significantly decreased the proliferation of GC cells, whereas NTN1 overexpression had an opposing effect. Furthermore, the use ...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Conditioned medium mimicking the tumor microenvironment augments chemotherapeutic resistance via ataxia‑telangiectasia mutated and nuclear factor‑κB pathways in gastric cancer cells. Oncol Rep. 2018 Aug 07;: Authors: Zhuang X, Li X, Zhang J, Hu Y, Hu B, Shi Y, Sun Y, Hong G Abstract The tumor microenvironment affects the processes involved in the development of gastric cancer and contributes to multidrug resistance (MDR). Although the metabolism of gastric cancer cells is known to be associated with the development of the tumor microenvironment, the exact role of metabolism in microenvironmen...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Association between Tim‑3 and Gal‑9 expression and gastric cancer prognosis. Oncol Rep. 2018 Aug 06;: Authors: Wang Y, Zhao E, Zhang Z, Zhao G, Cao H Abstract The T‑cell immunoglobulin and mucin domain‑containing protein 3 (Tim‑3)/galectin 9 (Gal‑9) pathway, which serves a pivotal role in immune regulation, is similar to the programmed death (PD)‑1/PD‑ligand 1 pathway. Recent evidence has suggested that Tim‑3 is differentially regulated in a variety of tumors and is a potential therapeutic target. The aim of the present study was to evaluate Tim‑3 and Gal‑9 expression an...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
MicroRNA‑181a promotes cell proliferation and inhibits apoptosis in gastric cancer by targeting RASSF1A. Oncol Rep. 2018 Aug 07;: Authors: Yu J, Qi J, Sun X, Wang W, Wei G, Wu Y, Gao Q, Zheng J Abstract MicroRNA (miR)‑181a is a member of the miR‑181 family that serves a key role in the pathogenesis of various cancer types. The present study aimed to investigate the interaction between miR‑181a and Ras association domain family protein1 isoform A (RASSF1A), and their roles in gastric carcinogenesis. The interaction between miR‑181a and RASSF1A was assessed in cell lines and cancer tissues. The...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
This study provides a comprehensive portrait of global changes in mRNA splicing signatures that occur in gastric cancer. These results allowed the identification of a core set of AS in gastric cancer and indicated that AS events may serve as prognostic indicators. PMID: 30106437 [PubMed - as supplied by publisher]
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Authors: Duan S, Gong B, Wang P, Huang H, Luo L, Liu F Abstract Gastric cancer (GC) is the fifth most common malignancy and the third leading cause of cancer‑associated mortality in the world. However, its mechanisms of occurrence and development have not been clearly elucidated. Furthermore, there is no effective tumor marker for GC. Using DNA microarray analysis, the present study revealed genetic alterations, screened out core genes as novel markers and discovered pathways for potential therapeutic targets. Differentially expressed genes (DEGs) between GC and adjacent normal tissues were identified, followed b...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
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