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No hormone-based contraceptive risk-free, study finds

New birth control methods that use lower doses of hormones to prevent pregnancy still increase a woman ’s risk of breast cancer by 20 percent, according to a study of 1.8 million Danish women published in the New England Journal of Medicine.  The study of health data from 1.8 million women in Denmark found 68 cases of breast cancer occurring annually in every 100,000 women using hormonal birth co ntrol versus 55 cases a year among nonusers, The New York Times reported.  Dr. Marisa Weiss, an oncologist…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news

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This article is protected by copyright. All rights reserved. PMID: 29450965 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Tags: J Thromb Haemost Source Type: research
AbstractBackgroundPregnancy affects breast cancer risk but how it affects the subtype and prognosis remain controversial. We studied the effect of parity and time since last birth on breast cancer subtype and outcome.Patients and methodsWe conducted a retrospective multivariate cohort study including all premenopausal women with early breast cancer aged  ≤ 50 years (N = 1306) at diagnosis at the University Hospitals Leuven (Jan. 2000–Dec. 2009). Primary study endpoints were the breast cancer subtype, disease-free survival, and distant disease-free survival by parity and time since last bir...
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
AbstractThe paper is motivated by severe concerns regarding currently applied care of the pregnancy-associated breast cancer (PABC) characterised by particularly poor outcomes of the disease. Psychological and ethical aspects play a crucial role in PABC: the highest priority not to damage the foetus significantly complicates any treatment generally, and it is quite usual that patients disclaim undergoing any breast cancer treatment during pregnancy. Although, due to global demographic trends, PABC is far from appearing rarely now, severe societal and economic consequences of the disease are still neglected by currently app...
Source: EPMA Journal - Category: International Medicine & Public Health Source Type: research
AbstractPurpose of ReviewTo describe the imaging evaluation of common benign and malignant breast lesions encountered in pregnant or lactating women.Recent FindingsThere is increasing prevalence of pregnancy-associated breast cancer as the age of  women during pregnancy increases. Women in the first 10 years following pregnancy demonstrate an elevated risk for breast cancer compared to the average population. MRI has been shown to be more sensitive for evaluating the extent of disease in lactating patients than mammography or ultrasound.SummaryThe hormonal effects of pregnancy and lactation on the breast lea...
Source: Current Radiology Reports - Category: Radiology Source Type: research
ConclusionsThe CA 15-3 assay using 115D8 –DF3 antibody pair is more suitable for monitoring therapy in pregnancy-associated breast cancer.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - Category: Hematology Authors: Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research
In conclusion, while participants differed somewhat from the baseline cohort, selection bias was limited after factors that associated with participation status were accounted for. PMID: 29346474 [PubMed - as supplied by publisher]
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research
Young women with breast cancer have always caught the attention of both clinicians and researchers, despite this group being a rarity. Several factors distinguish the biology of both breast cancer in young patients and the patients themselves from that of tumours and patients who are diagnosed later in life. Additionally, the cancers might be associated with a previous pregnancy or have a pathogenesis that is based on a genetic predisposition; some data even imply that both cancers associated with a previous pregnancy and a genetic predisposition to cancer might be directly connected.
Source: The Lancet Oncology - Category: Cancer & Oncology Authors: Tags: Comment Source Type: research
Publication date: Available online 6 January 2018 Source:Steroids Author(s): Cecilia J. Proietti, Mauro E. Cenciarini, Patricia V. Elizalde Progesterone receptor (PR) is a master regulator in female reproductive tissues that controls developmental processes and proliferation and differentiation during the reproductive cycle and pregnancy. PR also plays a role in progression of endocrine-dependent breast cancer. As a member of the nuclear receptor family of ligand-dependent transcription factors, the main action of PR is to regulate networks of target gene expression in response to binding its cognate steroid hormone, prog...
Source: Steroids - Category: Drugs & Pharmacology Source Type: research
Abstract Insofar as altered estrogen receptor-progesterone receptor (PR) expression contribute to breast cancer pathogenesis, previous studies examined the association of genetic variation in PR gene (PGR) with breast cancer, but with mixed outcome. We evaluated the association between PGR variants, and breast cancer and associated features. A retrospective case-control study involving 183 female breast cancer patients, and 222 control women. PGR genotyping was done by real-time PCR. Minor allele frequencies of rs1042838, rs590688, and rs10895068 PGR gene polymorphisms were significantly higher in breast cancer pa...
Source: Pathology Oncology Research - Category: Pathology Authors: Tags: Pathol Oncol Res Source Type: research
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