Acute lymphoblastic leukemia secondary to myeloproliferative neoplasms or after lenalidomide exposure

Key Clinical Message Philadelphia‐negative (Ph−) myeloproliferative neoplasms (MPN) do rarely transform to acute lymphoblastic leukemia (ALL). While causality is difficult to establish, a few cases of ALL arising after exposure to lenalidomide for registered indications (multiple myeloma, myelodysplastic syndrome with 5q deletion) have been described in the literature. Philadelphia‐negative (Ph−) myeloproliferative neoplasms (MPN) do rarely transform to acute lymphoblastic leukemia (ALL). While causality is difficult to establish, a few cases of ALL arising after exposure to lenalidomide for registered indications (multiple myeloma, myelodysplastic syndrome with 5q deletion) have been described in the literature.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fccr3.1264

Source: Clinical Case Reports - December 6, 2017 Category: General Medicine Authors: Ahmad Alhuraiji, Kiran Naqvi, Yang O. Huh, Coty Ho, Srdan Verstovsek, Prithviraj Bose Tags: Case Report Source Type: research