Platelet collagen receptor gpvi ‐dimer recognizes fibrinogen and fibrin through their d‐domains, contributing to platelet adhesion and activation during thrombus formation

ConclusionOnly dimeric GPVI interacts with fibrinogen D‐domain, at a site proximate to its collagen binding site, to support platelet adhesion/activation/aggregate formation on immobilized fibrinogen and polymerized fibrin.This article is protected by copyright. All rights reserved.

Source: Journal of Thrombosis and Haemostasis - December 1, 2017 Category: Hematology Authors: Isuru Induruwa, Masaaki Moroi, Arkadiusz Bonna, Jean ‐Daniel Malcor, Joanna‐Marie Howes, Elizabeth A. Warburton, Richard W. Farndale, Stephanie M. Jung Tags: Original Article ‐ Platelets Source Type: research