Feasibility and Safety of Controlled Active Hypothermia Treatment During Transport in Neonates With Hypoxic-Ischemic Encephalopathy
Objectives:
To evaluate the feasibility and safety of controlled active hypothermia versus standard intensive care during neonatal transport in patients with hypoxic-ischemic encephalopathy.
Design:
Cohort study with a historic control group.
Setting:
All infants were transported by Neonatal Emergency & Transport Services to a Level-III neonatal ICU.
Patients:
Two hundred fourteen term newborns with moderate-to-severe hypoxic-ischemic encephalopathy. An actively cooled group of 136 newborns were compared with a control group of 78 newborns.
Interventions:
Controlled active hypothermia during neonatal transport.
Measurements and Main Results:
Key measured variables were timing of hypothermia initiation, temperature profiles, and vital signs during neonatal transport. Hypothermia was initiated a median 2.58 hours earlier in the actively cooled group compared with the control group (median 1.42 [interquartile range, 0.83–2.07] vs 4.0 [interquartile range, 2.08–5.79] hours after birth, respectively; p
Source: Pediatric Critical Care Medicine - Category: Pediatrics Tags: Neonatal Intensive Care Source Type: research
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