A Selection Operator for Summary Association Statistics Reveals Allelic Heterogeneity of Complex Traits

In recent years, as a secondary analysis in genome-wide association studies (GWASs), conditional and joint multiple-SNP analysis (GCTA-COJO) has been successful in allowing the discovery of additional association signals within detected loci. This suggests that many loci mapped in GWASs harbor more than a single causal variant. In order to interpret the underlying mechanism regulating a complex trait of interest in each discovered locus, researchers must assess the magnitude of allelic heterogeneity within the locus.

Source: The American Journal of Human Genetics - November 30, 2017 Category: Genetics & Stem Cells Authors: Zheng Ning, Youngjo Lee, Peter K. Joshi, James F. Wilson, Yudi Pawitan, Xia Shen Tags: Article Source Type: research