Sertad1 antagonizes iASPP function by hindering its entrance into nuclei to interact with P53 in leukemic cells

As the important suppressor of P53, iASPP is found to be overexpressed in leukemia, and functions as oncogene that inhibited apoptosis of leukemia cells. Sertad1 is identified as one of the proteins that can b...

Source: BMC Cancer - November 28, 2017 Category: Cancer & Oncology Authors: Shaowei Qiu, Shuang Liu, Tengteng Yu, Jing Yu, Min Wang, Qing Rao, Haiyan Xing, Kejing Tang, Yinchang Mi and Jianxiang Wang Tags: Research article Source Type: research