An RNA structure-mediated, posttranscriptional model of human {alpha}-1-antitrypsin expression [Systems Biology]

Chronic obstructive pulmonary disease (COPD) affects over 65 million individuals worldwide, where α-1-antitrypsin deficiency is a major genetic cause of the disease. The α-1-antitrypsin gene, SERPINA1, expresses an exceptional number of mRNA isoforms generated entirely by alternative splicing in the 5′-untranslated region (5′-UTR). Although all SERPINA1 mRNAs encode exactly the...

Source: Proceedings of the National Academy of Sciences - November 21, 2017 Category: Science Authors: Meredith Corley, Amanda Solem, Gabriela Phillips, Lela Lackey, Benjamin Ziehr, Heather A. Vincent, Anthony M. Mustoe, Silvia B. V. Ramos, Kevin M. Weeks, Nathaniel J. Moorman, Alain Laederach Tags: PNAS Plus Source Type: research