Catechins Blunt the Effects of oxLDL and its Primary Metabolite Phosphatidylcholine Hydroperoxide on Endothelial Dysfunction Through Inhibition of Oxidative Stress and Restoration of eNOS in Rats

Conclusions: Our data suggests that catechins pretreatment decrease PCOOH-induced endothelial apoptosis and arterial vasoconstriction through the action of H2O2 inhibition and eNOS restoration.Kidney Blood Press Res 2017;42:919 –932
Source: Kidney and Blood Pressure Research - Category: Urology & Nephrology Source Type: research

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Abstract Objectives: To investigate the influence of statins on major adverse cardiovascular events (MACE) in patients with coronary microvascular dysfunction (CMVD). Participants: 23,494 patients who received coronary angiography (CAG) were included. Thrombolysis in Myocardial Infarction, Myocardial Perfusion Grading (TMPG), a useful angiographic method, was used to evaluate CMVD. Results: Using multivariate analysis, NYHA III/IV (HR, 1.44; 95% CI, 1.03-2.01; P=0.031), PCI history (HR, 3.69; 95% CI, 2.57-5.31; P
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Conclusion: Swept-source OCTA is a reproducible technique in the assessment of macular perfusion in diabetic patients with special regards to foveal avascular zone analysis. The agreement with FFA is limited especially for diabetic macular ischemia grading. Fundus fluorescein angiography is more sensitive in identifying microaneurysms.
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research
Xu Zhao1, Zhi-qiang Zhou2, Ying Xiong1, Xu Chen3, Ke Xu4, Juan Li1, Ying Hu1, Xiao-long Peng1 and Wen-zhen Zhu1* 1Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China 2Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China 3Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China 4Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science an...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Marjon E. Feenstra1†, Mirthe H. Schoots2†, Torsten Plösch1, Jelmer R. Prins1, Sicco A. Scherjon1, Albertus Timmer2, Harry van Goor2 and Sanne J. Gordijn1* 1Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands 2Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands Objective: Management of late fetal growth restriction (FGR) is limited to adequate fetal monitoring and optimal timing of delivery. The Disproportionate Intrauterine Growth Intervention ...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
This study is designed as a multicenter, computer-generated, randomized controlled, assessor-blind, parallel-group study with a superiority framework in patients scheduled for TARS. A total of 636 patients will be randomized on a 1:1 basis to a moderate hypothermia circulatory arrest (MHCA) group, which will receive selective ACP with moderate hypothermia during TARS; or to an RIVP group, which will receive the combination of RIVP and selective ACP under moderate hypothermia during TARS. The primary outcome will be a composite of early mortality and major complications, including paraplegia, postoperative renal failure, se...
Source: Trials - Category: Research Source Type: clinical trials
CONCLUSIONSThis suggested that hyper-frontal activity might contribute to compensation for cognitive dysfunction after pontine ischemia and that recovery from the cognitive deficits is attributable to frontal activity. PMID: 31006695 [PubMed - in process]
Source: NeuroRehabilitation - Category: Rehabilitation Tags: NeuroRehabilitation Source Type: research
Condition:   Acute Decompensated Heart Failure Intervention:   Diagnostic Test: Cardiac Perfusion and Metabolism with [11C] Acetate PET/CT Sponsor:   University of Alabama at Birmingham Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Most developing countries are currently unable to provide adequate, let alone advanced healthcare support to rural areas. Telemedicine combines the capability of information technology and dedicated people working towards the common goal of providing good quality healthcare in remote areas. In this article, the authors propose a system that can be used to transmit patient vitals like pulse rate, oxygen saturation, and perfusion index readings to a doctor in a remote area, while a patient is in transit. This system uses a smartphone application, a pulse oximeter, and the real-time data transferring capabilities of Firebase ...
Source: International Journal of E-Health and Medical Communications - Category: Information Technology Authors: Tags: Health Information Systems Medicine & Healthcare Source Type: research
Conclusion: We screened 12 receptor tyrosine kinases inhibitors, and EGFR/ErbB-2 and cFMS inhibitors were identified as novel antiepileptic compounds. Significance: This epilepsy-on-a-chip system provides the means for rapid dissection of complex signaling pathways in epileptogenesis, paving the way for high-throughput antiepileptic drug discovery.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Abstract BACKGROUND AND PURPOSE: Glioblastoma exhibits profound intratumoral heterogeneity in perfusion. Particularly, low perfusion may induce treatment resistance. Thus, imaging approaches that define low perfusion compartments are crucial for clinical management. MATERIALS AND METHODS: A total of 112 newly diagnosed glioblastoma patients were prospectively recruited for maximal safe resection. The apparent diffusion coefficient (ADC) and relative cerebral blood volume (rCBV) were calculated from diffusion and perfusion imaging, respectively. Based on the overlapping regions of lowest rCBV quartile (rCBVL) ...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
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