Role of immune microenvironment in gastrointestinal stromal tumours

ConclusionsPD‐L1 expression was associated with increased size and mitoses. High CD8+ or CD3+ TIL counts were associated with decreased PD‐L1/IDO+ GIST size. PD‐L1 and IDO could be significant in GIST tumour biology, which invites consideration of immunotherapy as a potential treatment option.

Source: Histopathology - November 21, 2017 Category: Pathology Authors: Andrew M Blakely, Andres Matoso, Pallavi A Patil, Ross Taliano, Jason T Machan, Thomas J Miner, Kara A Lombardo, Murray B Resnick, Li ‐Juan Wang Tags: Original Article Source Type: research