Rare, protein-truncating variants in ATM, CHEK2 and PALB2, but not XRCC2, are associated with increased breast cancer risks

Conclusions Truncating variants in PALB2 are associated with a higher risk of BC than those in ATM or CHEK2. A substantial risk of BC due to truncating XRCC2 variants can be excluded.

http://jmg.bmj.com/cgi/content/short/54/11/732?rss=1

Source: Journal of Medical Genetics - October 23, 2017 Category: Genetics & Stem Cells Authors: Decker, B., Allen, J., Luccarini, C., Pooley, K. A., Shah, M., Bolla, M. K., Wang, Q., Ahmed, S., Baynes, C., Conroy, D. M., Brown, J., Luben, R., Ostrander, E. A., Pharoah, P. D., Dunning, A. M., Easton, D. F. Tags: Evidence based practice, Open access Cancer genetics Source Type: research