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Neurofilaments in blood: (Almost) facing clinical application

Neurodegeneration is a critical pathophysiologic process of Alzheimer disease (AD) and related dementias, and correlates better with cognitive symptoms than the sole presence of pathologic proteins such as β-amyloid or α-synuclein. Thus, the identification of a biomarker that tracks with neurodegeneration is critical for following disease progression from the preclinical through the clinical phases and assessing rate of progression or therapeutic utility. The identification of a blood-based biomarker of neurodegeneration would be the Holy Grail. Compared to neuroimaging CSF collection, a blood draw is much less invasive and costly, has minimal side effects, is available in rural areas, and is feasible and acceptable by patients for serial testing to monitor disease progression and therapeutic response.
Source: Neurology - Category: Neurology Authors: Tags: EDITORIALS Source Type: research

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This article is protected by copyright. All rights reserved. • Bilaterally beta‐amyloid (Aβ) administration into the frontal cortex increased memory deficit, which intra‐peritoneal injection of crocin significantly improved Aβ‐induced spatial memory impairment. • Crocin treatment significantly attenuate c‐Fos level and neuronal apoptosis in hippocampus induced by Aβ administration into the frontal cortex. • Crocin antagonize the blocking effect of Aβ‐induced LTP deficits in freely moving rat.
Source: Synapse - Category: Neurology Authors: Tags: Research Article Source Type: research
A comprehensive genetic study has shed new light, not only on the role of APOE4 allele in brain amyloid deposition but also on the importance of other genes in this process as it relates to Alzheimer's disease.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news
High levels of beta amyloid combined with symptoms of anxiety and depression in cognitively normal older adults may signal preclinical Alzheimer's disease.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Psychiatry News Source Type: news
Authors: Snitz BE, Wang T, Cloonan YK, Jacobsen E, Chang CH, Hughes TF, Kamboh MI, Ganguli M Abstract INTRODUCTION: We compared risk of progression from subjective cognitive decline (SCD) to mild cognitive impairment (MCI) in an academic memory clinic versus a population-based study. METHODS: Older adults presenting at a memory clinic were classified as SCD (n = 113) or as noncomplainers (n = 82). Participants from a population study were classified as SCD (n = 592) and noncomplainers (n = 589) based on a memory complaint score. Annual follow-up performed for 3 years. ...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
While there are no drugs that can treat Alzheimer’s disease and reverse the memory and thinking problems it causes, a new study shows that some non-drug strategies may help to improve cognitive skills in some people with the illness. About 25% of people in the world are born with one copy of a gene, called APOE4, that is linked to a higher risk of developing Alzheimer’s. About 2% to 3% of the population has two copies of the gene — one from their mother and another from their father — that dramatically increases their risk for the disease. About 60% of those people will develop Alzheimer’s by ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Alzheimer's alzheimer's diet alzheimer's exericse alzheimer's genes alzheimer's lifestyle Brain diseases Genetics healthytime onetime Source Type: news
Can you remember what you had for dinner last night? How do you do it?byAlzheimer's Reading RoomThe temporal lobe,which contains the hippocampus, and the prefrontal cortex are important to episodic memory. This enables us to learn new information andremember recent events.The hippocampus is one of the first brain structures damaged in Alzheimer's disease.How Alzheimer's Affects the 4 Memory Systems of the BrainSubscribe to the Alzheimer's Reading - This is a Free Service - Join NowHow Your Brain Remembers What You Had for Dinner Last NightUC San Diego researchers find small sets of hippocampal neurons activate for each epi...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: brain memory memory systems of the brain remember research Source Type: blogs
This study is examining the combination of two novel interventions – transcranial direct current stimulation (tDCS) and cognitive remediation therapy – to protect against AD in patients with depression or mild cognitive impairment. The study is funded by Brain Canada and carried out by researchers in CAMH’s Geriatric Psychiatry Division in collaboration with Baycrest, St. Michael’s Hospital, Sunnybrook Health Sciences Centre and University Health Network. The Study in Context Solving the Brain Fitness Puzzle Is the Key to Self-Empowered Aging Important insights on the growing home use of tDCS...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology Alzheimers brain Brain-Fitness Brain-Training brain-training-exercises cognitive remediation cognitive-reserve dementia electrical stimulation mental-exercises Pfizer pharmace Source Type: blogs
This article is protected by copyright. All rights reserved. The selective loss of noradrenergic inputs to the hippocampus, induced by immunotoxic removal of noradrenergic neurons in the locus coeruleus, causes a severe impairment of working, but not reference memory, in the rat. These deficits can be ameliorated by intrahippocampal grafts of foetal noradrenergic progenitors, and are partly reinstated following their ablation. Interestingly, the noradrenergic‐rich transplants restore also the physiological (i.e. nuclear) expression pattern of TDP‐43 in various hippocampal subregions, whose pathological, cytoplasmic, o...
Source: The Journal of Comparative Neurology - Category: Neurology Authors: Tags: Research Article Source Type: research
(Natural News) Researchers have discovered a flower that can improve brain performance for patients with Alzheimer’s disease (AD). The results of the study were published in the African Journal of Traditional, Complementary, and Alternative Medicine. The paper, titled Protective effect of Iris germanica L. in b-amyloid-induced animal model of Alzheimer’s disease, studied the effects of the bearded iris in...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
You're reading 7 Reasons To Meditate, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. Do you always feel tired, stressed, and angry? Are you impulsive and can`t seem to stop snapping at people for the wrong reasons? If you say Yes, then you have to meditate more often. Why You Must Meditate Meditation is one of the best physical and spiritual activities you can gift yourself. For just 10 minutes each day, you can improve your mood, boost your energy and increase tranquility. But it`s not just about that. Researchers have ...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured health and fitness psychology self improvement alzheimer's health benefits of meditation meditate pickthebrain sleep aid Source Type: blogs
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