Neurofilaments in blood: (Almost) facing clinical application

Neurodegeneration is a critical pathophysiologic process of Alzheimer disease (AD) and related dementias, and correlates better with cognitive symptoms than the sole presence of pathologic proteins such as β-amyloid or α-synuclein. Thus, the identification of a biomarker that tracks with neurodegeneration is critical for following disease progression from the preclinical through the clinical phases and assessing rate of progression or therapeutic utility. The identification of a blood-based biomarker of neurodegeneration would be the Holy Grail. Compared to neuroimaging CSF collection, a blood draw is much less invasive and costly, has minimal side effects, is available in rural areas, and is feasible and acceptable by patients for serial testing to monitor disease progression and therapeutic response.
Source: Neurology - Category: Neurology Authors: Tags: EDITORIALS Source Type: research

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DISCUSSION: These findings may allow improved tracer-independent amyloid quantitation. PMID: 30006100 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Authors: Jacob JE, Cherian A, Gopakumar K, Iype T, Yohannan DG, Divya KP Abstract Chaotic analysis is a relatively novel area in the study of physiological signals. Chaotic features of electroencephalogram have been analyzed in various disease states like epilepsy, Alzheimer's disease, sleep disorders, and depression. All these diseases have primary involvement of the brain. Our study examines the chaotic parameters in metabolic encephalopathy, where the brain functions are involved secondary to a metabolic disturbance. Our analysis clearly showed significant lower values for chaotic parameters, correlation dimensi...
Source: Neurology Research International - Category: Neurology Tags: Neurol Res Int Source Type: research
New research offers 'the first population evidence for a causal link' between herpes infection and the development of Alzheimer's disease.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Alzheimer's / Dementia Source Type: news
Falls in older adults are common and debilitating. In the US alone, costs related to falls amounted to over 31 billion dollars; fall-related injury is among the top 20 most expensive medical conditions (1). One of the most serious fall injuries is hip fracture, seen in over 300,000 older adults yearly in the US (2). Hip fracture occurs more frequently in women, older adults, those with frailty associated with lower bone density (3), and those with neurodegenerative brain diseases such as Alzheimer's dementia (4).
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Regular Research Articles Source Type: research
Abstract Disturbances in both the ability to smell and to taste are common in older persons. Such disturbances influence nutrition, safety, quality of life, and psychological and physical health. The anatomic and physiologic causes of age-related disturbances are multiple and interacting, and depend on genetic and environmental factors. Frank losses of function, distortions, and hallucinations are common. Most distortions resolve over time, although this can take months or even years. Olfactory dysfunction occurs during the earliest stages of several neurologic disorders, most notably Alzheimer's disease and Parki...
Source: The Medical Clinics of North America - Category: General Medicine Authors: Tags: Otolaryngol Clin North Am Source Type: research
Antivirals could provide a treatment... → Enjoying these psych studies? Support PsyBlog for just $4 per month (includes ad-free experience and more articles). → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: NEW: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Dementia subscribers-only Source Type: blogs
Antivirals could provide a treatment... → Enjoying these psych studies? Support PsyBlog for just $4 per month (includes ad-free experience and more articles). → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: NEW: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Dementia Source Type: blogs
Publication date: July 2018Source: Alzheimer's &Dementia, Volume 14, Issue 7Author(s):
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Publication date: July 2018Source: Alzheimer's &Dementia, Volume 14, Issue 7Author(s):
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Publication date: July 2018Source: Alzheimer's &Dementia, Volume 14, Issue 7Author(s):
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
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