The potential of Ion Mobility Mass Spectrometry for high-throughput and high-resolution lipidomics.

The potential of Ion Mobility Mass Spectrometry for high-throughput and high-resolution lipidomics. Curr Opin Chem Biol. 2017 Nov 13;42:42-50 Authors: Hinz C, Liggi S, Griffin JL Abstract Lipids are a large and highly diverse family of biomolecules, which play essential structural, storage and signalling roles in cells and tissues. Although traditional mass spectrometry (MS) approaches used in lipidomics are highly sensitive and selective, lipid analysis remains challenging due to the chemical diversity of lipid structures, multiple isobaric species and incomplete separation using many forms of chromatography. Ion mobility (IM) separates ions in the gas phase based on their physicochemical properties. Addition of IM to the traditional lipidomic workflow both enhances separation of complex lipid mixtures, beneficial for lipid identification, and improves isomer resolution. Herein, we discuss the recent developments in IM-MS for lipidomics. PMID: 29145156 [PubMed - as supplied by publisher]
Source: Current Opinion in Chemical Biology - Category: Biochemistry Authors: Tags: Curr Opin Chem Biol Source Type: research