A T Cell Receptor Locus Harbors a Malaria-Specific Immune Response Gene

CD8+ T  cells that recognize MHC I-peptide complexes contribute to protection or pathogenesis after infection. Van Braeckel-Budimir et al. demonstrate that a germline-encoded component of the T cell receptor functions as an Immune response (Ir) gene, controlling the CD8+ T cell response against a malar ia epitope and the outcome of infection.

Source: Immunity - November 14, 2017 Category: Allergy & Immunology Authors: Natalija Van Braeckel-Budimir, Stephanie Gras, Kristin Ladell, Tracy M. Josephs, Lecia Pewe, Stina L. Urban, Kelly L. Miners, Carine Farenc, David A. Price, Jamie Rossjohn, John T. Harty Tags: Article Source Type: research